ArticleJournal of orthopaedic surgery and research2022
Association between serum ferritin and bone mineral density in US adults.
Article in Journal of orthopaedic surgery and research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Association of serum ferritin with bone turnover markers and bone mineral density in children and adolescents: Finding from NHANES 1999-2002.The Journal of international medical research · 2026Article
- Hereditary Hemochromatosis Type 2A Presenting With Hypogonadism, Diabetes, and Osteoporosis in a Young Woman.JCEM case reports · 2025Article
- Association of NLR and Ferritin in Osteoporotic Fractures Among Chinese Older Patients.Journal of inflammation research · 2025Article
- The association between the albumin to globulin ratio and thoracic spine bone mineral density in adolescents: NHANES 2011-2016.Frontiers in nutrition · 2025Article
- Article
- Long-Term Differential Effects of Gastric Bypass and Sleeve Gastrectomy on Bone Mineral Density.Journal of the Endocrine Society · 2024Article
- The Relationship between Bone Health Parameters, Vitamin D and Iron Status, and Dietary Calcium Intake in Young Males.Nutrients · 2024Article
- Association between the atherogenic index of plasma and bone mineral density among adult women: NHANES (2011-2018).Frontiers in endocrinology · 2024Observational
- The association of body mass index and weight waist adjustment index with serum ferritin in a national study of US adults.European journal of medical research · 2023Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe association between serum ferritin and bone mineral density (BMD) is still controversial. This study aims to investigate the association of serum ferritin level with BMD in US adults.
methodsWe conducted a cross-sectional study consisting of 8445 participants from National Health and Nutrition Examination Survey. Serum ferritin and lumbar spine BMD were used as independent variables and dependent variables, respectively. We evaluated the association between serum ferritin and lumbar spine BMD through a weighted multivariable linear regression model. Subgroup and interaction analysis was also performed in this study.
resultsAfter adjusting for other confounding factors, serum ferritin was negatively correlated with lumbar spine BMD [β = - 0.090, 95% CI (- 0.135, - 0.045)]. Further subgroup analysis found that the strongest negative association mainly exists in females aged over 45 years [β = - 0.169, 95% CI (- 0.259, - 0.079)], and this association is not significant in other groups.
conclusionsThe results found that the association between serum ferritin and lumber spine BMD differed by gender and age. Increased level of serum ferritin may indicate a higher risk of osteoporosis or osteopenia in females aged over 45 years.
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Registered trials
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