Evidence map›Paper›PMID 36384536›Full record

ArticleBMC cancer2022

Impact of GTF2H1 and RAD54L2 polymorphisms on the risk of lung cancer in the Chinese Han population.

Tingting Geng, Miao Li, Rong Chen, Shuangyu Yang, Guoquan Jin, Tinabo Jin, Fulin Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Tingting GengKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, #229 Taibai North Road, Xi'an, 710069, Shaanxi, China.
Miao LiDepartment of Medicine Oncology, The Fifth People's Hospital of Qinghai Province, 810007, Xining, Qinghai, China.
Rong ChenDepartment of Medicine Oncology, The Affiliated Hospital of Qinghai University, 810016, Xining, Qinghai, China.
Shuangyu YangKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, #229 Taibai North Road, Xi'an, 710069, Shaanxi, China.
Guoquan JinDepartment of Medicine Oncology, The Fifth People's Hospital of Qinghai Province, 810007, Xining, Qinghai, China.
Tinabo JinKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, #229 Taibai North Road, Xi'an, 710069, Shaanxi, China.
Fulin ChenKey Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Medicine, Northwest University, #229 Taibai North Road, Xi'an, 710069, Shaanxi, China. fulinchen0901@163.com.
Ministry of Education of the People's Republic of China · CNQinghai No.3 People's Hospital · CNNorthwest University · CNQinghai University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRepair pathway genes play an important role in the development of lung cancer. The study aimed to assess the correlation between single nucleotide polymorphisms (SNPs) in DNA repair gene (GTF2H1 and RAD54L2) and the risk of lung cancer.

methodsFive SNPs in GTF2H1 and four SNPs in RAD54L2 in 506 patients with lung cancer and 510 age-and gender-matched healthy controls were genotyped via the Agena MassARRAY platform. The influence of GTF2H1 and RAD54L2 polymorphisms on lung cancer susceptibility was assessed using logistic regression analysis by calculating odds ratios (ORs) and their corresponding 95% confidence intervals (CIs).

resultsRAD54L2 rs9864693 GC genotype increased the risk of lung cancer (OR = 1.33, 95%CI: 1.01-1.77, p = 0.045). Stratified analysis found that associations of RAD54L2 rs11720298, RAD54L2 rs4687592, RAD54L2 rs9864693 and GTF2H1 rs4150667 with lung cancer risk were found in subjects aged ≤ 59 years. Precisely, a protective effect of RAD54L2 rs11720298 on the occurrence of lung cancer was observed in non-smokers and drinkers. GTF2H1 rs4150667 was associated with a decreased risk of lung cancer in subjects with BMI ≤ 24 kg/m

conclusionOur study first revealed that RAD54L2 rs9864693 was associated with an increased risk of lung cancer in the Chinese Han population. This study may increase the understanding of the effect of RAD54L2 and GTF2H1 polymorphisms on lung cancer occurrence.

Indexed as

DNA HelicasesGenetic Predisposition to DiseaseLung NeoplasmsTranscription Factor TFIIHAsian PeopleChinaHumansPolymorphism, Single NucleotideDNA HelicasesGTF2H1 protein, humanRAD54L2 protein, humanTranscription Factor TFIIHGene polymorphismsGTF2H1Lung cancerMDR analysisRAD54L2

Identifiers

PMID36384536
PMCPMC9670636
OpenAlexW4309144619

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.