Evidence map›Paper›PMID 36384491›Full record

SynthesisBMC neurology2022

Anti-NMDA receptor encephalitis and MOG-associated demyelination - a case report with long-term follow-up and a systematic review.

Klaus Berek, Astrid Grams, Christian Uprimny, Manuela Prieschl, Melanie Ramberger, Iris Unterberger, Florian Deisenhammer, Markus Reindl, Harald Hegen

Open access · goldAbstract readSystematic ReviewCase Reports
In one paragraph

Synthesis in BMC neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. MOG Antibody Disease: Nuances in Presentation, Diagnosis, and Management.Current neurology and neuroscience reports · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Klaus BerekDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria.
Astrid GramsDepartment of Neuroradiology, Medical University of Innsbruck, Innsbruck, Austria.
Christian UprimnyDepartment of Nuclear Medicine, Medical University of Innsbruck, Innsbruck, Austria.
Manuela PrieschlDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria.
Melanie RambergerDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria.
Iris UnterbergerDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria.
Florian DeisenhammerDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria.
Markus ReindlDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria.
Harald HegenDepartment of Neurology, Medical University of Innsbruck, Anichstrasse 35, A-6020, Innsbruck, Austria. harald.hegen@i-med.ac.at.ORCID http://orcid.org/0000-0002-2833-6337
Innsbruck Medical University · AT

Funding

Austrian Science Fund FWF P 32699
6 · The paper itself

Abstract

backgroundOverlap syndromes of anti-NMDA receptor encephalitis and MOG-mediated demyelination have been reported. In this case we provide a long-term longitudinal follow-up of clinical and imaging characteristics as well as of antibody dynamics. CASE PRESENTATION: We report a 32-year-old male patient who presented with psychosis, decreased consciousness and movement disorders and was tested positive for anti-NMDA receptor antibodies. Forty-four months after symptom onset and diagnosis of autoimmune encephalitis, he suffered from relapse. At this time, the patient developed anti-MOG and anti-Caspr2 antibodies. Treatment with plasmapheresis, steroids and rituximab eventually led to substantial clinical and radiological improvement. Anti-Caspr2 antibodies persisted, anti-NMDA receptor antibodies decreased, while anti-MOG antibodies turned negative again.

conclusionWe provide long-term longitudinal follow-up of a patient with anti-NMDA receptor encephalitis who developed triple antibody positivity at the time of relapse. Antibody dynamics were associated with clinical disease course.

Indexed as

Anti-N-Methyl-D-Aspartate Receptor EncephalitisDemyelinating DiseasesAdultAutoantibodiesFollow-Up StudiesHumansMaleMyelin-Oligodendrocyte GlycoproteinNeoplasm Recurrence, LocalReceptors, N-Methyl-D-Aspartateanti-CASPR2 autoantibodyAutoantibodiesMyelin-Oligodendrocyte GlycoproteinReceptors, N-Methyl-D-AspartateAnti-N-Methyl-D-AspartateCase reportDemyelinationEncephalitisMyelin Oligodendrocyte GlycoproteinNMDA

Identifiers

PMID36384491
PMCPMC9667590
OpenAlexW4309322436

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.