Evidence map›Paper›PMID 36384465›Full record

ArticleBMC nephrology2022

A study protocol for improving the delivery of acute kidney replacement therapy (KRT) to critically ill patients in Alberta - DIALYZING WISELY.

Dawn Opgenorth, Sean M Bagshaw, Vincent Lau, Michelle M Graham, Nancy Fraser, Scott Klarenbach, Louise Morrin, Colleen Norris, Neesh Pannu, Selvi Sinnadurai and 3 more

Registry-linked trialAbstract read
In one paragraph

Article in BMC nephrology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05186636 (Dialyzing Wisely - Improving the Delivery of Acute Renal Replacement Therapy to Albertans), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05186636 completednot on this mapstarted 2023, after this paper: background citation

Dialyzing Wisely - Improving the Delivery of Acute Renal Replacement Therapy to Albertans

TypeobservationalSponsorUniversity of AlbertaRan2023 to 2026Enrolled9,348ConditionsAcute Renal InjuryArmsKPI reports, Prescriber reports
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Key Performance Indicators Applied in Medicine.International archives of otorhinolaryngology · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Dawn OpgenorthDepartment of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta and Alberta Health Services, CSB 2-124 8440 112th St NW, Edmonton, Alberta, T6G 2B7, Canada. dawno@ualberta.ca.ORCID 0000-0003-3571-3871
Sean M BagshawDepartment of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta and Alberta Health Services, CSB 2-124 8440 112th St NW, Edmonton, Alberta, T6G 2B7, Canada.
Vincent LauDepartment of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta and Alberta Health Services, CSB 2-124 8440 112th St NW, Edmonton, Alberta, T6G 2B7, Canada.
Michelle M GrahamDepartment of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
Nancy FraserCritical Care Strategic Clinical Network, Alberta Health Services, Edmonton, Alberta, Canada.
Scott KlarenbachDepartment of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
Louise MorrinDepartment of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
Colleen NorrisCardiovascular Health and Stroke Strategic Clinical Network, Alberta Health Services, Edmonton, Alberta, Canada.
Neesh PannuDepartment of Medicine, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.
Selvi SinnaduraiCritical Care Strategic Clinical Network, Alberta Health Services, Edmonton, Alberta, Canada.
Shelley ValaireMaternal, Neonatal, Child and Youth Strategic Clinical Network, Alberta Health Services, Edmonton, Alberta, Canada.
Xiaoming WangHealth Services Statistical and Analytic Methods, Alberta Health Services, Edmonton, Alberta, Canada.
Oleksa G RewaDepartment of Critical Care Medicine, Faculty of Medicine and Dentistry, University of Alberta and Alberta Health Services, CSB 2-124 8440 112th St NW, Edmonton, Alberta, T6G 2B7, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute kidney replacement therapy (KRT) is delivered to acutely ill patients to support organ function and life in the Intensive Care Unit (ICU). Implementing standardized acute KRT pathways can ensure its safe and effective management. At present, there is no standardized approach to the management of acute KRT in Alberta ICUs.

methodsDialyzing Wisely is a registry embedded, stepped-wedge, interrupted time-series evaluation of the implementation of a standardized, stakeholder-informed, and evidence-based acute KRT pathway into Alberta ICUs. The acute KRT pathway will consist of two distinct phases. First, we will implement routine monitoring of evidence-informed key performance indicators (KPIs) of acute KRT. Second, we will provide prescriber and program reports for acute KRT initiation patterns. After the implementation of both phases of the pathway, we will evaluate acute KRT performance quarterly and implement a customized suite of interventions aimed at improving performance. We will compare this with baseline and evaluate iterative post implementation effects of the care pathway. DISCUSSION: Dialyzing Wisely will implement, monitor, and report a suite of KPIs of acute KRT, coupled with a care pathway that will transform the quality of acute KRT across ICUs in Alberta. This program will provide a framework for scaling evidence-informed approaches to monitoring and management of acute KRT in other jurisdictions. We anticipate improvements in acute KRT performance, decreased healthcare system costs and improved patient quality of life by decreasing patient dependence on maintenance dialysis.

trial registrationClinicaltrials.gov , NCT05186636. Registered 11, January, 2022.

Indexed as

Critical IllnessQuality of LifeAlbertaHumansRenal DialysisRenal Replacement TherapyAcute renal replacement therapyCare pathway integrationCritical care medicineIntensive care

Identifiers

PMID36384465
PMCPMC9670635

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.