ArticleBone & joint research2022
Wound fluid ceftriaxone concentrations after local application with calcium sulphate as carrier material in the treatment of orthopaedic device-associated hip infections.
Article in Bone & joint research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Gentamicin fails to eradicateJournal of bone and joint infection · 2026Article
- Short-term follow-up of antibiotic-loaded calcium sulfate in treating chronic periprosthetic joint infection during two-stage revision.Frontiers in bioengineering and biotechnology · 2025Article
- Successful Implant Retention in a Chronified Hematogenous Bilateral Periprosthetic Hip Joint Infection WithArthroplasty today · 2024Article
- The immediate ex vivo covering and filling characteristics of antibiotic-loaded resorbable calcium sulfate paste around intramedullary nails.Journal of bone and joint infection · 2024Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThere is a considerable challenge in treating bone infections and orthopaedic device-associated infection (ODAI), partly due to impaired penetration of systemically administrated antibiotics at the site of infection. This may be circumvented by local drug administration. Knowledge of the release kinetics from any carrier material is essential for proper application. Ceftriaxone shows a particular constant release from calcium sulphate (CaSO
methodsA total of 30 operations with ceftriaxone-loaded CaSO
resultsA total of 37 wound fluid concentrations from 16 operations performed in 14 patients were collected. The ceftriaxone concentrations remained approximately within a range of 100 to 200 mg/l up to three weeks. The median concentration was 108.9 mg/l (interquartile range 98.8 to 142.5) within the first ten days. No systemic adverse reactions were observed.
conclusionOur study highlights new clinical data of locally administered ceftriaxone with CaSO
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