ArticleThrombosis and haemostasis2023
Genetic Predisposition of Both Waist Circumference and Hip Circumference Increased the Risk of Venous Thromboembolism.
Article in Thrombosis and haemostasis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Global Research Hotspots and Trends in Obesity-Related Venous Thromboembolism (2000-2025): a Bibliometric Analysis.Obesity surgery · 2026Article
- Association of triglyceride-glucose related indices with the incidence of venous thromboembolism: a nationwide prospective cohort study based on the UK Biobank.BMC cardiovascular disorders · 2026Article
- Joint effects of waist circumference trajectories and aging with risk of heart disease.BMC cardiovascular disorders · 2026Article
- Polycystic ovary syndrome and risk of pregnancy-induced hypertension, gestational diabetes mellitus, and preeclampsia: a Bayesian Mendelian randomization study.Diabetology & metabolic syndrome · 2025Article
- Sex-specific Mendelian randomization phenome-wide association study of basal metabolic rate.Scientific reports · 2025Article
- Article
- The relationship between mental health problems and risk of infectious diseases: A Mendelian randomization analysis.Medicine · 2024Article
- Venous Thromboembolism and Obesity: Moving Toward a Better Understanding of the Population-Attributable Risk.Thrombosis and haemostasis · 2024Article
- Causal associations between atrial fibrillation and breast cancer: A bidirectional Mendelian randomization analysis.Cancer medicine · 2024Article
- Causations between obesity, diabetes, lifestyle factors and the risk of low back pain.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2024Article
- Causal associations of particulate matter 2.5 and cardiovascular disease: A two-sample mendelian randomization study.PloS one · 2024Article
- Article
- Mapping the Four Adiposity Axes-Inflammatory Cytokine-Venous Thromboembolism Risk Landscape: A Two-Step Mediation Mendelian Randomization Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundObesity, especially abdominal obesity, is an independent indicator of increased cardiovascular risk. Observational studies have shown an observational association between obesity and venous thromboembolism (VTE). As a type of VTE, pulmonary embolism (PE) is also associated with obesity. However, it is unclear whether the observed associations are causal or caused by confounding bias or reverse causality.
methodsWe performed a two-sample test by obtaining the exposure dataset of waist circumference (WC) and hip circumference (HC) from the Neale Laboratory Consortium's genome-wide association study summary data and the summary-level outcome data of VTE and PE from FinnGen Biobank of European ancestry to determine the causal effect of WC and HC on VTE and PE.
resultsAll three Mendelian randomization methods displayed a positive association between WC/HC and VTE/PE. WC and HC were positively associated with VTE (odds ratio [OR] = 1.803 per 1 standard deviation [SD] increase in WC, 95% confidence interval [CI] = 1.393-2.333;
conclusionThere is a significant causal relationship between WC/HC and VTE/PE, which is consistent with observational studies. Taking measures to reduce WC/HC of obesity may help reduce the incidence of VTE/PE.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.