Evidence map›Paper›PMID 36384160›Full record

ArticleJournal of clinical periodontology2023

FasL is a catabolic factor in alveolar bone homeostasis.

Karol Alí Apaza Alccayhuaman, Patrick Heimel, Jung Seok Lee, Stefan Tangl, Ulrike Kuchler, Julie Marchesan, Layla Panahipour, Stefan Lettner, Eva Matalová, Reinhard Gruber

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical periodontology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Serum cytokines in periodontal diseases.Periodontology 2000 · 2025
    Review
  2. Review
  3. Article
  4. Article
  5. FasL is a catabolic factor in alveolar bone homeostasis.Journal of clinical periodontology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 5 countries.

Karol Alí Apaza AlccayhuamanDepartment of Oral Biology, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-4565-5222
Patrick HeimelKarl Donath Laboratory for Hard Tissue and Biomaterial Research, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria.
Jung Seok LeeDepartment of Oral Biology, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-1276-5978
Stefan TanglKarl Donath Laboratory for Hard Tissue and Biomaterial Research, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria.
Ulrike KuchlerDepartment of Oral Surgery, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria.
Julie MarchesanDivision of Comprehensive Oral Health, Adams School of Dentistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Layla PanahipourDepartment of Oral Biology, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria.
Stefan LettnerKarl Donath Laboratory for Hard Tissue and Biomaterial Research, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria.
Eva MatalováLaboratory of Odontogenesis and Osteogenesis, Institute of Animal Physiology and Genetics, Czech Academy of Sciences, Brno, Czech Republic.
Reinhard GruberDepartment of Oral Biology, University Clinic of Dentistry, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-5400-9009
Medical University of Vienna · ATAustrian Cluster for Tissue Regeneration · ATCzech Academy of Sciences, Institute of Animal Physiology and Genetics · CZLudwig Boltzmann Institute for Traumatology, The Research Center in Cooperation with AUVA · ATUniversity of Bern · CHUniversity of North Carolina at Chapel Hill · USYonsei University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimFas ligand (FasL) belongs to the tumour necrosis factor superfamily regulating bone turnover, inflammation, and apoptosis. The appendicular and axial skeleton phenotype of mature Fasl MATERIALS AND

methodsWe performed a phenotypical analysis of mice carrying the homozygous Fasl

resultsHealthy Fasl

conclusionsOur findings suggest that FasL is a catabolic factor in alveolar bone homeostasis but it does not affect the inflammatory osteolysis.

Indexed as

OsteolysisAnimalsFas Ligand ProteinHomeostasisMiceMice, Inbred C57BLX-Ray MicrotomographyFas Ligand ProteinFasLgldligatureosteolysisperiodontitis

Identifiers

PMID36384160
PMCPMC10946845
OpenAlexW4309246122

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.