Evidence map›Paper›PMID 36384146›Full record

ReviewClinical and molecular hepatology2023

Non-alcoholic fatty liver disease: the pathologist's perspective.

Wei-Qiang Leow, Anthony Wing-Hung Chan, Paulo Giovanni L Mendoza, Regina Lo, Kihan Yap, Haeryoung Kim

Open access · goldAbstract readReview
In one paragraph

Review in Clinical and molecular hepatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
7.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Efficacy of interventions with live combinedFrontiers in pharmacology · 2025
    Pooled it
  2. Review
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  7. Review
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  11. Review
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  13. Therapeutic potential of3 Biotech · 2025
    Article
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  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Wei-Qiang LeowDepartment of Anatomical Pathology, Singapore General Hospital, Singapore, Singapore.
Anthony Wing-Hung ChanDepartment of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong, China.
Paulo Giovanni L MendozaPathology and Laboratory Department, Cardinal Santos Medical Center, San Juan, Philippines.
Regina LoDepartment of Pathology and State Key Laboratory of Liver Research (HKU), The University of Hong Kong, Hong Kong, China.
Kihan YapYong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Haeryoung KimDepartment of Pathology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Chinese University of Hong Kong · HKNational University of Singapore · SGSeoul National University Hospital · KRSingapore General Hospital · SGUniversity of Hong Kong · HK

Funding

Ministry of Science and ICTNational Research Foundation of Korea 2022R1A2C2010348
6 · The paper itself

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a spectrum of diseases characterized by fatty accumulation in hepatocytes, ranging from steatosis, non-alcoholic steatohepatitis, to cirrhosis. While histopathological evaluation of liver biopsies plays a central role in the diagnosis of NAFLD, limitations such as the problem of interobserver variability still exist and active research is underway to improve the diagnostic utility of liver biopsies. In this article, we provide a comprehensive overview of the histopathological features of NAFLD, the current grading and staging systems, and discuss the present and future roles of liver biopsies in the diagnosis and prognostication of NAFLD.

Indexed as

Non-alcoholic Fatty Liver DiseaseBiopsyHepatocytesHumansLiverLiver CirrhosisPathologistsBiopsyDiagnosisHistologyNon-alcoholic fatty liver diseasePrognosis

Identifiers

PMID36384146
PMCPMC10029955
OpenAlexW4309098910

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.