Evidence map›Paper›PMID 36384139›Full record

ArticleCurrent biology : CB2022

TES-1/Tes and ZYX-1/Zyxin protect junctional actin networks under tension during epidermal morphogenesis in the C. elegans embryo.

Allison M Lynch, Yuyun Zhu, Bethany G Lucas, Jonathan D Winkelman, Keliya Bai, Sterling C T Martin, Samuel Block, Mark M Slabodnick, Anjon Audhya, Bob Goldstein and 3 more

Open access · greenAbstract read
In one paragraph

Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Apical spectrin organizes cortical actin filament bundles to patternbioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Temporal Analysis of Embryonic Epidermal Morphogenesis inInternational journal of molecular sciences · 2025
    Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Allison M LynchProgram in Genetics, University of Wisconsin, Madison, WI 53706, USA.
Yuyun ZhuProgram in Genetics, University of Wisconsin, Madison, WI 53706, USA.
Bethany G LucasDepartment of Biology, Regis University, 3333 Regis Boulevard, Denver, CO 80221, USA.
Jonathan D WinkelmanInstitute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, USA.
Keliya BaiUniversity of Aberdeen, Institute of Medical Sciences, Aberdeen AB25 2ZD, UK.
Sterling C T MartinBiophysics Program, University of Wisconsin, Madison, WI 53706, USA.
Samuel BlockDepartment of Biomolecular Chemistry, University of Wisconsin, Madison, WI 53706, USA.
Mark M SlabodnickDepartment of Biology, Knox University, Galesburg, IL 61401, USA; Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Anjon AudhyaDepartment of Biomolecular Chemistry, University of Wisconsin, Madison, WI 53706, USA.
Bob GoldsteinDepartment of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Jonathan PettittUniversity of Aberdeen, Institute of Medical Sciences, Aberdeen AB25 2ZD, UK.
Margaret L GardelInstitute for Biophysical Dynamics, University of Chicago, Chicago, IL 60637, USA; Department of Physics, James Franck Institute and Pritzker School of Molecular Engineering, University of Chicago, Chicago, IL 60637, USA.
Jeff HardinProgram in Genetics, University of Wisconsin, Madison, WI 53706, USA; Biophysics Program, University of Wisconsin, Madison, WI 53706, USA; Department of Integrative Biology, University of Wisconsin, Madison, WI 53706, USA. Electronic address: jdhardin@wisc.edu.
University of Wisconsin–Madison · USUniversity of Aberdeen · GBUniversity of Chicago · USUniversity of North Carolina at Chapel Hill · USRegis University · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Tension-dependent regulation of alpha-catenin during morphogenesis in C. elegansR01GM058038 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI HARDIN, JEFFREY D · 1998 to 2021
$6.2M
Molecular mechanisms that regulate vesicle formation and transportR35GM134865 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Anjon Audhya · 2020 to 2026
$4.8M
Regulation of dynamic actin networks during epithelial morphogenesisR35GM145312 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Jeffrey D Hardin · 2022 to 2026
$3.0M
C. elegans Gastrulation: a Model for Understanding Apical Constriction MechanismsR35GM134838 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT P GOLDSTEIN · 2020 to 2026
$2.9M
Mechanical Regulation of Cell Adhesion by Dynamic Cytoskeletal Assemblies - Resubmission 01R01GM104032 · NIGMS · UNIVERSITY OF CHICAGO · PI GARDEL, MARGARET LISE · 2015 to 2023
$2.5M
Mechanosensing in LIM Domain ProteinsF32GM122372 · NIGMS · UNIVERSITY OF CHICAGO · PI WINKELMAN, JONATHAN DAVID · 2017 to 2019
$179k
Investigating the mechanisms that regulate apical constriction during C. elegans gastrulation.F32GM119348 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SLABODNICK, MARK MADDOCK · 2016 to 2017
$111k
NIGMS NIH HHS F32 GM119348NIGMS NIH HHS F32 GM122372NIGMS NIH HHS R01 GM058038NIGMS NIH HHS R01 GM104032NIGMS NIH HHS R35 GM134838NIGMS NIH HHS R35 GM134865NIGMS NIH HHS R35 GM145312NIH HHS P40 OD010440
6 · The paper itself

Abstract

LIM-domain-containing repeat (LCR) proteins are recruited to strained actin filaments within stress fibers in cultured cells,

Indexed as

ActinsCaenorhabditis elegansAnimalsActinscadherinC. eleganscell-cell adhesionF-actinLIM-domain-containing proteinmechanobiologymorphogenesisTeszyxinα-catenin

Identifiers

PMID36384139
PMCPMC9729467
OpenAlexW4309195580

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.