Multimodal Genotype and Phenotype Data Integration to Improve Partial Data-Based Longitudinal Prediction.

Multimodal data analysis has attracted ever-increasing attention in computational biology and bioinformatics community recently. However, existing multimodal learning approaches need all data modalities available at both training and prediction stages, thus they cannot be applied to many real-world biomedical applications, which often have a missing modality problem as the collection of all modalities is prohibitively costly. Meanwhile, two diagnosis-related pieces of information are of main interest during the examination of a subject regarding a chronic disease (with longitudinal progression): their current status (diagnosis) and how it will change before next visit (longitudinal outcome). Correct responses to these queries can identify susceptible individuals and provide the means of early interventions for them. In this article, we develop a novel adversarial mutual learning framework for longitudinal disease progression prediction, allowing us to leverage multiple data modalities available for training to train a performant model that uses a single modality for prediction. Specifically, in our framework, a single-modal model (which utilizes the