ArticleScience translational medicine2022
Visualization of exhaled breath metabolites reveals distinct diagnostic signatures for acute cardiorespiratory breathlessness.
Article in Science translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07379567 (Application of Rapid Detection of Exhaled Volatile Organic Compounds in the Emergency Department for Differentiating High-Risk Chest Pain Patients), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Application of Rapid Detection of Exhaled Volatile Organic Compounds in the Emergency Department for Differentiating High-Risk Chest Pain Patients
Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Editorial for the Special Issue "Applications of Biomedical Imaging and Sensing Technologies in Disease Diagnosis".Sensors (Basel, Switzerland) · 2026Article
- Nanomaterial-Enabled Fiber-Optic SPR Biosensor for Continuous and Noninvasive Body Fluid Monitoring:Progress and Prospects.Nanomaterials (Basel, Switzerland) · 2026Review
- Biomolecular profiling for noninvasive health monitoring.Nature biotechnology · 2026Review
- Harnessing breath biomarkers for pneumonia diagnosis and prognosis.Expert review of respiratory medicine · 2026Review
- Miniaturized olfactory sensor chip-based AI-wearable biometric ring for human body metabolic odor analysis.Nature communications · 2026Article
- Precision Medicine for Asthma: Tailored to its Severity and Endotype/Phenotype.Allergy, asthma & immunology research · 2026Review
- Developments in the Management Strategies for Allergy: Advances in Artificial Intelligence and Future Perspectives.Anti-inflammatory & anti-allergy agents in medicinal chemistry · 2026Review
- AI-driven breath biopsy from a case-control study assists in the early detection of paediatric brain tumours.EBioMedicine · 2025Article
- Targeted high-resolution sensing of volatile organic compounds by covalent nanopore detection.Nature communications · 2025Article
- Artificial neural network risk prediction of COPD exacerbations using urine biomarkers.ERJ open research · 2025Article
- Oscillometry to assess ventilation heterogeneity during hospital admission for acute cardiorespiratory illness.ERJ open research · 2025Article
- Exhaled Breath Analysis: From Laboratory Test to Wearable Sensing.IEEE reviews in biomedical engineering · 2025Review
- Exhaled breath metabolites reveal postmenopausal gut-bone cross-talk and non-invasive markers for osteoporosis.Communications medicine · 2024Article
- Article
- Discovery and Validation of a Volatile Signature of Eosinophilic Airway Inflammation in Asthma.American journal of respiratory and critical care medicine · 2024Article
- Fulfilling the Promise of Breathomics: Considerations for the Discovery and Validation of Exhaled Volatile Biomarkers.American journal of respiratory and critical care medicine · 2024Review
- A smart mask for exhaled breath condensate harvesting and analysis.Science (New York, N.Y.) · 2024Article
- Progress and challenges of developing volatile metabolites from exhaled breath as a biomarker platform.Metabolomics : Official journal of the Metabolomic Society · 2024Review
- Plasmonic Alloys Enhanced Metabolic Fingerprints for the Diagnosis of COPD and Exacerbations.ACS central science · 2024Article
- Dissecting causal relationships between immune cells, plasma metabolites, and COPD: a mediating Mendelian randomization study.Frontiers in immunology · 2024Article
Corrections and comments
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Authors and funding
28 authors at 4 institutions in 3 countries.
Funding
Abstract
Acute cardiorespiratory breathlessness accounts for one in eight of all emergency hospitalizations. Early, noninvasive diagnostic testing is a clinical priority that allows rapid triage and treatment. Here, we sought to find and replicate diagnostic breath volatile organic compound (VOC) biomarkers of acute cardiorespiratory disease and understand breath metabolite network enrichment in acute disease, with a view to gaining mechanistic insight of breath biochemical derangements. We collected and analyzed exhaled breath samples from 277 participants presenting acute cardiorespiratory exacerbations and aged-matched healthy volunteers. Topological data analysis phenotypes differentiated acute disease from health and acute cardiorespiratory exacerbation subtypes (acute heart failure, acute asthma, acute chronic obstructive pulmonary disease, and community-acquired pneumonia). A multibiomarker score (101 breath biomarkers) demonstrated good diagnostic sensitivity and specificity (≥80%) in both discovery and replication sets and was associated with all-cause mortality at 2 years. In addition, VOC biomarker scores differentiated metabolic subgroups of cardiorespiratory exacerbation. Louvain clustering of VOCs coupled with metabolite enrichment and similarity assessment revealed highly specific enrichment patterns in all acute disease subgroups, for example, selective enrichment of correlated C5-7 hydrocarbons and C3-5 carbonyls in heart failure and selective depletion of correlated aldehydes in acute asthma. This study identified breath VOCs that differentiate acute cardiorespiratory exacerbations and associated subtypes and metabolic clusters of disease-associated VOCs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.