ArticleScience translational medicine2022
APOE ε4 genotype, amyloid-β, and sex interact to predict tau in regions of high APOE mRNA expression.
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Sex differences in Alzheimer's disease: a systematic review of two decades of neuroimaging research.The British journal of radiology · 2026Pooled it
- A critical appraisal of the link between apolipoprotein E and Tau.Current opinion in neurology · 2026Review
- Emerging pathological mechanisms of Alzheimer's disease pathogenesis: from neuroimmune interactions to intercellular communication.Frontiers in aging neuroscience · 2026Review
- ApoE4 Upregulates GSK-3β to Aggravate Alzheimer-Like Pathologies and Cognitive Impairment in Type 2 Diabetic Mice.CNS neuroscience & therapeutics · 2025Article
- Article
- Longitudinal associations between lipid panel and cognitive decline modified by APOE 4 carrier status in biracial community-dwelling older adults: Findings from the Chicago health and aging project.Archives of gerontology and geriatrics · 2025Article
- Personalised regional modelling predicts tau progression in the human brain.PLoS biology · 2025Article
- APOE4, Blood Neurodegenerative Biomarkers, and Cognitive Decline in Community-Dwelling Older Adults.JAMA network open · 2025Article
- Integrating amyloid and tau imaging with proteomics and genomics in Alzheimer's disease.Cell reports. Medicine · 2024Review
- Apolipoprotein E in Alzheimer's disease trajectories and the next-generation clinical care pathway.Nature neuroscience · 2024Review
- Article
- Disease staging of Alzheimer's disease using a CSF-based biomarker model.Nature aging · 2024Article
- Spatial transcriptomic patterns underlying amyloid-β and tau pathology are associated with cognitive dysfunction in Alzheimer's disease.Cell reports · 2024Article
- Innovative Multivariable Model Combining MRI Radiomics and Plasma Indexes Predicts Alzheimer's Disease Conversion: Evidence from a 2-Cohort Longitudinal Study.Research (Washington, D.C.) · 2024Article
- APOEε4 potentiates amyloid β effects on longitudinal tau pathology.Nature aging · 2023Article
- Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy.Acta neuropathologica communications · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 3 institutions in 2 countries.
Aylin DincerMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0000-0003-2388-0840
Charles D ChenMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0000-0001-6698-1268
Nicole S McKayMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0000-0003-4123-2548
Lauren N KoenigMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0000-0003-2279-4510
Austin McCulloughMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0000-0001-9192-111X
Shaney FloresMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0000-0003-2726-8704
Sarah J KeefeMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0000-0002-5943-0940
Stephanie A SchultzMassachusetts General Hospital, Boston, MA 02114, USA.
Rebecca L FeldmanMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0000-0002-0762-0515
Nelly Joseph-MathurinMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0000-0002-9735-5152
Russ C HornbeckMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0000-0002-9519-6223
Carlos CruchagaKnight Alzheimer Disease Research Center, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0000-0002-0276-2899
Suzanne E SchindlerKnight Alzheimer Disease Research Center, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0000-0002-1680-1465
David M HoltzmanKnight Alzheimer Disease Research Center, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0000-0002-3400-0856
John C MorrisKnight Alzheimer Disease Research Center, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0000-0001-9820-5618
Anne M FaganKnight Alzheimer Disease Research Center, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Tammie L S BenzingerMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0000-0002-8114-0552
Brian A GordonMallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO 63110, USA.ORCID 0000-0003-2109-2955
Mallinckrodt (United States) · USWashington University in St. Louis · USMassachusetts General Hospital · US
Funding
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5MThe natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5MWashington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4MResearch Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI DAVID M. HOLTZMAN · 2020 to 2026
$28.7MTHE XNAT IMAGING INFORMATICS PLATFORMR01EB009352 · NIBIB · WASHINGTON UNIVERSITY · PI Daniel Scott Marcus · 2009 to 2026
$9.3MUSING QUANTITATIVE TRAITS TO IDENTIFY NOVEL GENES FOR ALZHEIMERS DISEASE AND OTHER COMPLEX TRAITSRF1AG053303 · NIA · WASHINGTON UNIVERSITY · PI CLIMER, SHARLEE, CRUCHAGA, CARLOS · 2016 to 2020
$4.0MIdentifying Rare Variants that Increase Risk for Alzheimer's DiseaseRF1AG044546 · NIA · WASHINGTON UNIVERSITY · PI CRUCHAGA, CARLOS · 2019 to 2019
$3.6MNINDS CENTER CORE FOR BRAIN IMAGINGP30NS098577 · NINDS · WASHINGTON UNIVERSITY · PI HERSHEY, TAMARA G, MARCUS, DANIEL SCOTT · 2016 to 2019
$2.4MPURCHASE OF A SIEMENS NEXT GENERATION PET/CTS10OD025214 · OD · WASHINGTON UNIVERSITY · PI WOODARD, PAMELA K · 2018 to 2018
$2.0MHIGH PERFORMANCE BIOMEDICAL IMAGING COMPUTER RESOURCESS10RR022984 · NCRR · WASHINGTON UNIVERSITY · PI PRIOR, FRED WILLIAM · 2009 to 2009
$1.9MNeuroimaging Markers of Emerging Dysfunction In Preclinical Alzheimer DiseaseK01AG053474 · NIA · WASHINGTON UNIVERSITY · PI GORDON, BRIAN ANDREW · 2017 to 2021
$623kGPU COMPUTING RESOURCE TO ENABLE INNOVATION IN IMAGING AND NETWORK BIOLOGYS10OD018091 · OD · WASHINGTON UNIVERSITY · PI PAPPU, ROHIT V, PRIOR, FRED WILLIAM · 2014 to 2014
$598kNCATS NIH HHS UL1 TR000448NCRR NIH HHS S10 RR022984NIA NIH HHS K01 AG053474NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG066444NIA NIH HHS RF1 AG044546NIA NIH HHS RF1 AG053303NIBIB NIH HHS R01 EB009352NIH HHS S10 OD018091NIH HHS S10 OD025214NINDS NIH HHS P30 NS098577
Abstract
The apolipoprotein E (
Indexed as
Alzheimer DiseaseApolipoprotein E4Amyloid beta-PeptidesApolipoproteins EBrainFemaleGenotypeHumansPositron-Emission TomographyRNA, Messengertau ProteinsAmyloid beta-PeptidesApolipoprotein E4Apolipoproteins ERNA, Messengertau Proteins
Identifiers
What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.