ArticleScience translational medicine2022
Food-specific immunoglobulin A does not correlate with natural tolerance to peanut or egg allergens.
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Article in Science translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- Diet-Microbiome-Immune Interactions at the Gut Mucosa in Food Allergy: Mechanisms, Gaps, and Therapeutic Implications.Allergy · 2026Review
- Early-Life Biomarkers in Food Allergy Development: A Systematic Review of Immunological and Intestinal Pathways.Biomedicines · 2026Review
- Mixed Signals: T Cells as Architects of IgE Immunity.Immunological reviews · 2026Review
- Mechanisms of IgE-mediated food allergy and the role of allergen-specific B cells.FEBS letters · 2026Review
- Oral Immunotherapy-Induced Changes in IgE, IgG, and IgA: A Review of Antibody Isotype Shifts and Their Clinical Relevance in Food Allergy.Antibodies (Basel, Switzerland) · 2026Review
- Farm exposure in infancy is associated with elevated systemic IgGScience translational medicine · 2025Article
- Article
- Gut mucosal immune responses - Implications for celiac disease and food allergy.Seminars in immunology · 2025Review
- Diet Components, Immune Function and IgE-Mediated Food Allergy.Nutrients · 2025Review
- Food allergy: begin at the skin, end at the mast cell?Nature reviews. Immunology · 2025Review
- Advances in Food Allergy Immunotherapy: Current Strategies and Role of Antibodies Isotypes.Cells · 2025Review
- A new experimental model of peanut allergy in BALB/c and C57BL/6 mice.Frontiers in allergy · 2025Article
- All roads lead to IgA: Mapping the many pathways of IgA induction in the gut.Immunological reviews · 2024Review
- Saliva antibody profiles are associated with reaction threshold and severity of peanut allergic reactions.The Journal of allergy and clinical immunology · 2024Article
- Whence and wherefore IgE?Immunological reviews · 2024Review
- Single-Domain Antibodies-Novel Tools to Study and Treat Allergies.International journal of molecular sciences · 2024Review
- Metabolic fitness of IgAMucosal immunology · 2024Article
- Feast for thought: A comprehensive review of food allergy 2021-2023.The Journal of allergy and clinical immunology · 2024Review
- Allergen-specific IgA and IgG antibodies as inhibitors of mast cell function in food allergy.Frontiers in allergy · 2024Review
- The future of food allergy diagnosis.Frontiers in allergy · 2024Review
Corrections and comments
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Authors and funding
26 authors at 10 institutions in 2 countries.
Elise G LiuDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0002-7507-5045
Biyan ZhangDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0003-0329-2451
Victoria MartinDepartment of Pediatrics, Harvard Medical School, Harvard University, Boston, MA 02115, USA.ORCID 0000-0002-4322-9564
John AnthonypillaiDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0002-6109-5811
Magdalena KraftDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
Alexander GrishinDivision of Pediatric Allergy and Immunology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-4799-4324
Galina GrishinaDivision of Pediatric Allergy and Immunology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0002-1801-7586
Jason R CatanzaroSection of Pulmonology, Allergy, Immunology, and Sleep Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06510, USA.ORCID 0000-0003-2630-8882
Sharon ChinthrajahSean N. Parker Center for Allergy and Asthma Research, Stanford, CA 94040, USA.
Tina SindherSean N. Parker Center for Allergy and Asthma Research, Stanford, CA 94040, USA.ORCID 0000-0003-0387-2800
Monali ManoharSean N. Parker Center for Allergy and Asthma Research, Stanford, CA 94040, USA.
Antonia Zoe QuakeSean N. Parker Center for Allergy and Asthma Research, Stanford, CA 94040, USA.ORCID 0000-0001-7697-4985
Kari NadeauSean N. Parker Center for Allergy and Asthma Research, Stanford, CA 94040, USA.ORCID 0000-0002-2146-2955
A Wesley BurksUniversity of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.ORCID 0000-0003-1873-5702
Edwin H KimUniversity of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.ORCID 0000-0001-6418-1785
Michael D KulisUniversity of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.ORCID 0000-0001-8092-7444
Alice K HenningEmmes, Rockville, MD 20850, USA.ORCID 0000-0002-6338-6890
Stacie M JonesDepartment of Pediatrics, University of Arkansas for Medical Sciences and Arkansas Children's Hospital, Little Rock, AR 72205, USA.ORCID 0000-0003-3491-4815
Donald Y M LeungDepartment of Pediatrics, Division of Pediatric Allergy-Immunology, National Jewish Health, Denver, CO 80206, USA.ORCID 0000-0002-0177-3844
Scott H SichererDivision of Pediatric Allergy and Immunology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-0036-0439
Robert A WoodDepartment of Pediatrics, Division of Allergy, Immunology, and Rheumatology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.ORCID 0000-0003-3777-802X
Qian YuanDepartment of Pediatrics, Harvard Medical School, Harvard University, Boston, MA 02115, USA.
Wayne ShrefflerDepartment of Pediatrics, Harvard Medical School, Harvard University, Boston, MA 02115, USA.ORCID 0000-0001-6465-137X
Hugh SampsonDivision of Pediatric Allergy and Immunology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.ORCID 0000-0003-1613-8875
Veronika ShabanovaDepartment of Pediatrics, Yale University School of Medicine, New Haven, CT 06510, USA.
Stephanie C EisenbarthDepartment of Laboratory Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.ORCID 0000-0002-1244-208X
Yale University · USInstitute for Asthma and Allergy · USIcahn School of Medicine at Mount Sinai · USBroad Institute · USUniversity of North Carolina at Chapel Hill · USAgency for Science, Technology and Research · SGArkansas Children's Hospital · USEmmes (United States) · USJohns Hopkins University · USNational Jewish Health · US
Funding
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MNIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1MPilot Project for the DTMI CRA ProgramUL1RR024128 · NCRR · DUKE UNIVERSITY · PI CALIFF, ROBERT M · 2006 to 2010
$48.1MMechanistic CoreU19AI066738 · NIAID · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SAMPSON, HUGH A · 2005 to 2016
$43.6MMount Sinai Institutes for Clinical and Translational SciencesUL1TR000067 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI SAMPSON, HUGH A · 2012 to 2014
$16.5MFood Allergy Research Consortium and Statistical CenterU01AI066560 · NIAID · THE EMMES COMPANY, LLC · PI DAWSON, PETER RUSSELL, LINDBLAD, ROBERT · 2005 to 2016
$12.8MArkansas Center for Clinical and Translational ResearchUL1TR000039 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI BECK, CORNELIA MARIE, JAMES, LAURA P · 2012 to 2014
$10.0MTRAINING PROGRAM IN INVESTIGATIVE RHEUMATOLOGYT32AR007107 · NIAMS · YALE UNIVERSITY · PI RICHARD J BUCALA · 1986 to 2026
$7.5MImmune Mechanisms Regulating AllergyR01AI136942 · NIAID · YALE UNIVERSITY · PI Stephanie Caroline Eisenbarth, ADAM WILLIAMS · 2018 to 2026
$5.1MArkansas Center for Food Allergy Research (ArCOFAR)UM1AI130781 · NIAID · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI JONES, STACIE M · 2017 to 2023
$1.6MSystems approach to elucidate the microbiome's influence on the development of food allergies early in lifeK23AI151556 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI MARTIN, VICTORIA MACKENZIE · 2021 to 2025
$998kThe adaptive immune response to food antigens in the gutR56AI155497 · NIAID · YALE UNIVERSITY · PI EISENBARTH, STEPHANIE CAROLINE · 2021 to 2021
$448kNCATS NIH HHS U13 TR003935NCATS NIH HHS UL1 TR000039NCATS NIH HHS UL1 TR000067NCATS NIH HHS UL1 TR002535NCRR NIH HHS UL1 RR024128NCRR NIH HHS UL1 RR025005NIAID NIH HHS K23 AI151556NIAID NIH HHS R01 AI136942NIAID NIH HHS R56 AI155497NIAID NIH HHS U01 AI066560NIAID NIH HHS U19 AI066738NIAID NIH HHS UM1 AI130781NIAMS NIH HHS T32 AR007107
Abstract
ImmunoglobulinA (IgA) is the predominant antibody isotype in the gut, where it regulates commensal flora and neutralizes toxins and pathogens. The function of food-specific IgA in the gut is unknown but is presumed to protect from food allergy. Specifically, it has been hypothesized that food-specific IgA binds ingested allergens and promotes tolerance by immune exclusion; however, the evidence to support this hypothesis is indirect and mixed. Although it is known that healthy adults have peanut-specific IgA in the gut, it is unclear whether children also have gut peanut-specific IgA. We found in a cohort of non-food-allergic infants (
Indexed as
Food HypersensitivityPeanut HypersensitivityAdultAllergensArachisChildEpitopesHumansImmunoglobulin AInfantAllergensEpitopesImmunoglobulin A
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