Evidence map›Paper›PMID 36383664›Full record

ArticleScience advances2022

Single-digit-micrometer-resolution continuous liquid interface production.

Kaiwen Hsiao, Brian J Lee, Tim Samuelsen, Gabriel Lipkowitz, Jason M Kronenfeld, Dan Ilyn, Audrey Shih, Maria T Dulay, Lee Tate, Eric S G Shaqfeh and 1 more

Abstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. In Situ Characterisation of Hydrogels via Dynamic Interface Printing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Lithography-based 3D printing of hydrogels.Nature reviews bioengineering · 2025
    Article
  14. Review
  15. Review
  16. Article
  17. High-resolution stereolithography: Negative spaces enabled by control of fluid mechanics.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  18. Growing three-dimensional objects with light.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kaiwen HsiaoDepartment of Radiology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-9585-0002
Brian J LeeDepartment of Radiology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-8931-3956
Tim SamuelsenDepartment of Mechanical Engineering, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-7437-4908
Gabriel LipkowitzDepartment of Mechanical Engineering, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0003-4869-6804
Jason M KronenfeldDepartment of Chemistry, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-3026-2736
Dan IlynDepartment of Mechanical Engineering, Stanford University, Stanford, CA 94305, USA.
Audrey ShihDepartment of Chemical Engineering, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-8489-2178
Maria T DulayDepartment of Radiology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-4678-3480
Lee TateDigital Light Innovations, Austin, TX 78728, USA.
Eric S G ShaqfehDepartment of Mechanical Engineering, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0001-8241-2946
Joseph M DeSimoneDepartment of Radiology, Stanford University, Stanford, CA 94305, USA.ORCID 0000-0002-1764-8634

Funding

Stanford Molecular Imaging Scholars (SMIS) ProgramT32CA118681 · NCI · STANFORD UNIVERSITY · PI CRAIG S LEVIN · 2016 to 2026
$4.3M
NCI NIH HHS T32 CA118681Wellcome Trust
6 · The paper itself

Abstract

To date, a compromise between resolution and print speed has rendered most high-resolution additive manufacturing technologies unscalable with limited applications. By combining a reduction lens optics system for single-digit-micrometer resolution, an in-line camera system for contrast-based sharpness optimization, and continuous liquid interface production (CLIP) technology for high scalability, we introduce a single-digit-micrometer-resolution CLIP-based 3D printer that can create millimeter-scale 3D prints with single-digit-micrometer-resolution features in just a few minutes. A simulation model is developed in parallel to probe the fundamental governing principles in optics, chemical kinetics, and mass transport in the 3D printing process. A print strategy with tunable parameters informed by the simulation model is adopted to achieve both the optimal resolution and the maximum print speed. Together, the high-resolution 3D CLIP printer has opened the door to various applications including, but not limited to, biomedical, MEMS, and microelectronics.

Identifiers

PMID36383664
PMCPMC9668307

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.