ArticleScience advances2022
Astrocyte dysfunction drives abnormal resting-state functional connectivity in depression.
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Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39citing papers in PubMed
4.2field-weighted citation impact, top 4% of its field
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Who cites it
39 citing papers in PubMed, 69 citations in OpenAlex.
- Glymphatic system dysfunction: a link between sleep disorders and neurodegeneration.Psychopharmacology · 2026Review
- Sex Differences in Depression: Adult Cytogenesis as Potential Target for Precision Psychiatry.Cells · 2026Review
- Cumulative mild stress during early life alters prefrontal astrocytic proteins and elevates peripheral S100B in young adult mice.Translational psychiatry · 2026Article
- Astrocyte-Driven Modulation of Whole-Brain Functional Networks and BOLD Signals Revealed by Optogenetic-fMRI.Neuroscience bulletin · 2026Article
- Integrating optogenetic fMRI and spatial transcriptomics to reveal circuit-specific gene signatures in fronto- and hippo-thalamic networks.Nature communications · 2026Article
- Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive-Like Behaviors.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- TransBrain: a computational framework for translating brain-wide phenotypes between humans and mice.Nature methods · 2026Article
- Advances in chemogenetics: a review of DREADDs and its application in psychiatric disorders.Molecular psychiatry · 2026Review
- Chronic Stress and Astrocyte Dysfunction in Depression: Molecular Mechanisms and Gene Expression Changes.Antioxidants (Basel, Switzerland) · 2025Review
- Differential brain regional activity and connectivity of anterior cingulate cortex between major depressive disorder with and without suicidal ideation under resting state.Psychological medicine · 2025Article
- Adenosine A2A signaling in mood disorders: How far have we come?IBRO neuroscience reports · 2025Article
- Presence of Astrocytic S1R/5-HT1A Heterocomplex in the mPFC: A Putative Link to S1R Activation Mediated Faster Antidepressant-Like Effects.Molecular neurobiology · 2025Article
- Astrocyte Store-Released Calcium Modulates Visual Cortex Synapse Development and Circuit Function.Research square · 2025Article
- Osteocalcin modulates hippocampal activities and influences glycophagy within astrocytes in a chronic unpredictable mild stress mouse model.Comprehensive psychoneuroendocrinology · 2025Article
- Brain-Wide Spatiotemporally Distinct Traveling Waves Drive Anxiety-Like Behaviors in Mice.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Role of astrocyte in neuroinflammation-induced loss in neuroplasticity and subsequent onset of depression: A systematic review.Neuroprotection (Chichester, England) · 2025Review
- When the Stars Misfire: Astrocytic Dysfunctions in Major Depressive Disorder.Neurochemical research · 2025Review
- Correlations between depressive symptoms, verbal working memory, and physical activity in university students: evidence based on resting EEG.BMC psychiatry · 2025Article
- Dural Tregs driven by astrocytic IL-33 mitigate depression through the EGFR signals in mPFC neurons.Cell death and differentiation · 2025Article
- Mesoscale brain-wide fluctuation analysis: revealing ketamine's rapid antidepressant across multiple brain regions.Translational psychiatry · 2025Article
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 2 countries.
Jiaming LiuSchool of Biomedical Engineering, Southern Medical University, Guangzhou, China.ORCID 0000-0001-9666-0684
Jia-Wen MoKey Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.ORCID 0000-0001-8099-791X
Xunda WangLaboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.ORCID 0000-0001-7933-0755
Ziqi AnSchool of Biomedical Engineering, Southern Medical University, Guangzhou, China.ORCID 0000-0002-8544-8749
Shuangyang ZhangSchool of Biomedical Engineering, Southern Medical University, Guangzhou, China.ORCID 0000-0001-8025-4737
Can-Yuan ZhangKey Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.ORCID 0000-0003-1521-1794
Peiwei YiSchool of Biomedical Engineering, Southern Medical University, Guangzhou, China.ORCID 0000-0001-5632-5654
Alex T L LeongLaboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.ORCID 0000-0003-1633-0445
Jing RenKey Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.ORCID 0000-0002-8223-8762
Liang-Yu ChenKey Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.ORCID 0000-0001-7149-785X
Ran MoKey Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.ORCID 0000-0001-9906-0967
Yuanyao XieSchool of Biomedical Engineering, Southern Medical University, Guangzhou, China.ORCID 0000-0002-6781-5971
Qianjin FengSchool of Biomedical Engineering, Southern Medical University, Guangzhou, China.ORCID 0000-0002-3830-5120
Wufan ChenSchool of Biomedical Engineering, Southern Medical University, Guangzhou, China.ORCID 0000-0002-4125-7537
Tian-Ming GaoKey Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.ORCID 0000-0003-4594-9052
Ed X WuLaboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong SAR, China.ORCID 0000-0001-5581-1546
Yanqiu FengSchool of Biomedical Engineering, Southern Medical University, Guangzhou, China.ORCID 0000-0002-2807-5974
Xiong CaoKey Laboratory of Mental Health of the Ministry of Education, Guangdong-Hong Kong-Macao Greater Bay Area Center for Brain Science and Brain-Inspired Intelligence, Guangdong Province Key Laboratory of Psychiatric Disorders, Department of Neurobiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou 510515, China.ORCID 0000-0002-1889-4255
Southern Medical University · CNUniversity of Hong Kong · HKThe First People's Hospital of Shunde · CNZhujiang Hospital · CN
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major depressive disorder (MDD) is a devastating mental disorder that affects up to 17% of the population worldwide. Although brain-wide network-level abnormalities in MDD patients via resting-state functional magnetic resonance imaging (rsfMRI) exist, the mechanisms underlying these network changes are unknown, despite their immense potential for depression diagnosis and management. Here, we show that the astrocytic calcium-deficient mice, inositol 1,4,5-trisphosphate-type-2 receptor knockout mice (
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