ArticleScience advances2022
Chronic exposure to carbon black ultrafine particles reprograms macrophage metabolism and accelerates lung cancer.
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Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
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Who cites it
33 citing papers in PubMed, 70 citations in OpenAlex.
- Testosterone plus lifestyle therapy improves skeletal muscle glycolysis in older men with obesity and hypogonadism.Frontiers in endocrinology · 2025Trial
- Adverse Effects of Carbon Black Nanoparticles on Maternal and Fetal Lungs in Pregnant Mice: Insights From a Metabolomics Perspective.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Hallmarks of lung cancer driven by inhalable particulate matter: From cell-intrinsic oncogenic traits to microenvironment remodeling.Innovation (Cambridge (Mass.)) · 2026Review
- Impact of particulate matter 2.5 on a mouse model of lung adenocarcinoma.BMC pulmonary medicine · 2026Article
- Targeting metabolic-epigenetic-immune axis in cancer: molecular mechanisms and therapeutic implications.Signal transduction and targeted therapy · 2026Review
- Systemic distribution of tricyclo-DNA antisense oligonucleotide following intratracheal instillation in the mouse.NAR molecular medicine · 2026Article
- The impact of mixed exposure to PMFrontiers in public health · 2026Article
- Examining the Interaction between Allergic Asthma and Air Pollution: a Potential Role for Trained Immunity.Current allergy and asthma reports · 2025Review
- Heterogeneous impact of fine particulate matter constituents on pulmonary tuberculosis onset: a multicenter time series study in Beijing.BMC public health · 2025Article
- [PM2.5-induced M2 Polarization and IL-1α Secretion by Tumor-associated Macrophages Promotes Lung Adenocarcinoma Progression].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2025Article
- Immunoregulatory mechanisms in the aging microenvironment: Targeting the senescence-associated secretory phenotype for cancer immunotherapy.Acta pharmaceutica Sinica. B · 2025Review
- N6-methyladenosine-modified circDCP2 promotes carbon black nanoparticle-induced malignancy in human bronchial epithelial cells via PI3K-AKT pathway and macrophage homeostasis.Journal of nanobiotechnology · 2025Article
- Particulate matter air pollution as a cause of lung cancer: epidemiological and experimental evidence.British journal of cancer · 2025Review
- Update in Association between Lung Cancer and Air Pollution.Tuberculosis and respiratory diseases · 2025Article
- MAGE-A4 induces non-small cell lung cancer and tumor-promoting plasma cell accumulation.Science advances · 2025Article
- Linking macrophage metabolism to function in the tumor microenvironment.Nature cancer · 2025Review
- Article
- Unlocking the secrets of glucose metabolism reprogramming: the role in pulmonary diseases.Frontiers in pharmacology · 2025Review
- Multi-stage mechanisms of tumor metastasis and therapeutic strategies.Signal transduction and targeted therapy · 2024Review
- Cellular senescence and metabolic reprogramming: Unraveling the intricate crosstalk in the immunosuppressive tumor microenvironment.Cancer communications (London, England) · 2024Review
Corrections and comments
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Authors and funding
26 authors at 4 institutions in 1 country.
Cheng-Yen ChangTranslational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-3943-3044
Ran YouDepartment of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Dominique ArmstrongTranslational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-6669-0911
Ashwini BandiDepartment of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-0483-1309
Yi-Ting ChengDevelopmental Biology Program, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-8288-0707
Philip M BurkhardtImmunology and Microbiology Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-6290-6532
Luis Becerra-DominguezImmunology and Microbiology Graduate Program, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-7007-9402
Matthew C MadisonTranslational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA.
Hui-Ying TungDepartment of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Zhimin ZengDepartments of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA.
Yifan WuDepartment of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-3996-7310
Lizhen SongDepartment of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-2448-7795
Patricia E PhillipsCytometry and Cell Sorting Core, Baylor College of Medicine, Houston TX 77030, USA.
Paul PorterCytometry and Cell Sorting Core, Baylor College of Medicine, Houston TX 77030, USA.
John M KnightDepartment of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-0070-6893
Nagireddy PutluriDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-4488-7400
Xiaoyi YuanDepartment of Anesthesiology, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX 77030, USA.ORCID 0000-0002-2898-6495
Daniela C MarcanoDepartment of Chemistry and Smalley-Curl Institute, NanoCarbon Center, The Welch Institute for Advanced Materials, and Department of Materials Science and NanoEngineering, Rice University, Houston, TX 77005 USA.
Emily A McHughDepartment of Chemistry and Smalley-Curl Institute, NanoCarbon Center, The Welch Institute for Advanced Materials, and Department of Materials Science and NanoEngineering, Rice University, Houston, TX 77005 USA.
James M TourDepartment of Chemistry and Smalley-Curl Institute, NanoCarbon Center, The Welch Institute for Advanced Materials, and Department of Materials Science and NanoEngineering, Rice University, Houston, TX 77005 USA.ORCID 0000-0002-8479-9328
Andre CaticTranslational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0002-3572-7598
Laure ManeixCenter for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-0044-5395
Bryan M BurtDepartment of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.
Hyun-Sung LeeDepartment of Medicine, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-8259-046X
David B CorryTranslational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-9729-1016
Farrah KheradmandTranslational Biology and Molecular Medicine Program, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-5343-103X
Baylor College of Medicine · USRice University · USMichael E. DeBakey VA Medical Center · USThe University of Texas Health Science Center · US
Funding
Tumor BiologyP30CA125123 · NCI · BAYLOR COLLEGE OF MEDICINE · PI Michael M Ittmann · 2007 to 2026
$73.9MConvalescent Plasma to Limit Coronavirus Associated ComplicationsUL1TR003167 · NCATS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KARP, DANIEL D, MCPHERSON, DAVID D · 2019 to 2023
$45.3MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007330 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI PLON, SHARON E. · 1985 to 2019
$15.6MTranslational Research Support CoreP30ES030285 · NIEHS · BAYLOR COLLEGE OF MEDICINE · PI Casey W Wright · 2019 to 2026
$14.7MMentored Experiences in Research, Instruction and Teaching (MERIT) Program - administrative supplementK12GM088010 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SCHNEIDER, DAVID ALAN · 2009 to 2024
$9.2MHematology Training ProgramT32DK060445 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI GOODELL, MARGARET A. · 2002 to 2023
$8.3MImmunology Scientist Training ProgramT32AI053831 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI CORRY, DAVID B · 2003 to 2018
$4.2MPathogenesis of Polymicrobial Cerebritis-Related DementiaR01AI135803 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI CORRY, DAVID B, KHERADMAND, FARRAH · 2018 to 2022
$3.8MTraining Program in Translational Biology and Molecular MedicineT32GM088129 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI ROONEY, CLIONA M., VAN DEN VEYVER, IGNATIA B · 2010 to 2019
$3.0MProteomic determinants of response to checkpoint blockade in malignant pleuralmesotheliomaR37CA248478 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Bryan Michael Burt · 2021 to 2026
$2.9MRole of Let-7 as genetic modifier of Alzheimer's DiseaseR01HL140398 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI CORRY, DAVID B, RODRIGUEZ, ANTONY · 2018 to 2022
$2.4MTargeting Myeloid Dependent MicroRNAs in Acute Respiratory Distress SyndromeR01HL155950 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Xiaoyi Yuan · 2022 to 2026
$2.0MBLRD VA I01 BX004828CSRD VA I01 CX000104NCATS NIH HHS UL1 TR003167NCI NIH HHS P30 CA125123NCI NIH HHS R37 CA248478NCRR NIH HHS S10 RR024574NHLBI NIH HHS R01 HL117181NHLBI NIH HHS R01 HL140398NHLBI NIH HHS R01 HL155950NIAID NIH HHS R01 AI135803NIAID NIH HHS T32 AI053831NIDDK NIH HHS R01 DK115454NIDDK NIH HHS T32 DK060445NIEHS NIH HHS R01 ES029442NIGMS NIH HHS K12 GM088010NIGMS NIH HHS T32 GM007330NIGMS NIH HHS T32 GM088129NIOSH CDC HHS T42 OH008421
Abstract
Chronic exposure to airborne carbon black ultrafine (nCB) particles generated from incomplete combustion of organic matter drives IL-17A-dependent emphysema. However, whether and how they alter the immune responses to lung cancer remains unknown. Here, we show that exposure to nCB particles increased PD-L1
Indexed as
Lung NeoplasmsSootAnimalsCarbonLungMacrophagesMiceParticulate MatterTumor MicroenvironmentCarbonParticulate MatterSoot
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LicenceCC BY-NC
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.