ArticleScience advances2022
Blind identification of the spinal cord output in humans with high-density electrode arrays implanted in muscles.
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Probabilistic inference of homonymous and heteronymous recurrent inhibition in human muscles from large-scale motor neuron recordings.Science advances · 2026Article
- Mental tasks induce common modulations of oscillations in cortex and spinal cord.Journal of neuroengineering and rehabilitation · 2026Article
- Implanted microelectrode arrays in reinnervated muscles allow separation of neural drives from transferred polyfunctional nerves.Nature biomedical engineering · 2026Article
- Reinnervation of Muscle Targets Enhances the Separability of Motor Unit Signals Following Peripheral Nerve Transfers.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Wearable and Implantable Devices for Continuous Monitoring of Muscle Physiological Activity: A Review.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- High performance sorting of motor unit action potentials with EMUsort.bioRxiv : the preprint server for biology · 2026Article
- A single low-dimensional neural component of spinal motor neuron activity explains force generation across repetitive isometric tasks.iScience · 2025Article
- The effect of sensor-to-source distance on magnetic neuromuscular signals.Scientific reports · 2025Article
- Unlocking the full potential of high-density surface EMG: novel non-invasive high-yield motor unit decomposition.The Journal of physiology · 2025Article
- Hand kinematics, high-density sEMG comprising forearm and far-field potentials for motion intent recognition.Scientific data · 2025Article
- A motor unit action potential-based method for surface electromyography decomposition.Journal of neuroengineering and rehabilitation · 2025Article
- Recent Progress of Soft and Bioactive Materials in Flexible Bioelectronics.Cyborg and bionic systems (Washington, D.C.) · 2025Review
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- Emerging Value of Osseointegration for Intuitive Prosthetic Control after Transhumeral Amputations: A Systematic Review.Plastic and reconstructive surgery. Global open · 2024Article
- Peripheral neural interfaces: Skeletal muscles are hyper-reinnervated according to the axonal capacity of the surgically rewired nerves.Science advances · 2024Article
- Accessing populations of motor units.eLife · 2024Article
- First-in-human demonstration of floating EMG sensors and stimulators wirelessly powered and operated by volume conduction.Journal of neuroengineering and rehabilitation · 2024Article
- The neural control of movement: a century of in vivo motor unit recordings is the legacy of Adrian and Bronk.The Journal of physiology · 2024Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Invasive electromyography opened a new window to explore motoneuron behavior in vivo. However, the technique is limited by the small fraction of active motoneurons that can be concurrently detected, precluding a population analysis in natural tasks. Here, we developed a high-density intramuscular electrode for in vivo human recordings along with a fully automatic methodology that could detect the discharges of action potentials of up to 67 concurrently active motoneurons with 99% accuracy. These data revealed that motoneurons of the same pool receive common synaptic input at frequencies up to 75 Hz and that late-recruited motoneurons inhibit the discharges of those recruited earlier. These results constitute an important step in the population coding analysis of the human motor system in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.