ArticleACS chemical biology2022
Generating Efficient
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Article in ACS chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
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Who cites it
24 citing papers in PubMed, 26 citations in OpenAlex.
- Cold Orthogonal Translation: A Psychrophilic Pyrrolysyl-tRNA Synthetase Boosts Genetic Code Expansion in E. coli.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Efficient and Site-Specific Incorporation of 3-Nitro-Tyrosine Into Recombinant Proteins inBio-protocol · 2026Article
- Scalable Flow Synthesis of Genetically Encodable Tetrazine Amino Acids.Organic process research & development · 2026Article
- Selecting aminoacyl-tRNA synthetase/tRNA pairs for efficient genetic encoding of noncanonical amino acids into proteins.Nature protocols · 2026Review
- Expanding the Genetic Code with Lysine Aminoacylation.Journal of the American Chemical Society · 2026Article
- Endogenous Site-Specific Encoding of Trifluoromethyl-Bearing Phenylalanine and Tryptophan for in-CellJournal of the American Chemical Society · 2026Article
- Towards directed evolution of rare earth element binding peptides using genetically encoded sensitizing amino acids.Protein engineering, design & selection : PEDS · 2026Article
- Interactions of Neurodegenerative Disease Positron Emission Tomography Imaging Probe Candidates with the C-Terminus of α-Synuclein Fibrils.Chembiochem : a European journal of chemical biology · 2025Article
- High throughput screening of eukaryotic release factor 1 variants to enhance noncanonical amino acid incorporation.bioRxiv : the preprint server for biology · 2025Article
- Voltage sensor conformations induced by LQTS-associated mutations in hERG potassium channels.Nature communications · 2025Article
- Quantitative Protein Labeling in Live Cells by Controlling the Redox State of Encoded Tetrazines.Journal of the American Chemical Society · 2025Article
- Leveraging relaxation-optimizedNature chemistry · 2025Article
- Directed evolution of aminoacyl-tRNA synthetases through in vivo hypermutation.Nature communications · 2025Article
- Strategies to Expand the Genetic Code of Mammalian Cells.Chemical reviews · 2025Review
- Optogenetics with Atomic Precision─A Comprehensive Review of Optical Control of Protein Function through Genetic Code Expansion.Chemical reviews · 2025Review
- BeyondChemical reviews · 2025Review
- Reaching New Heights in Genetic Code Manipulation with High Throughput Screening.Chemical reviews · 2024Review
- Engineering Pyrrolysine Systems for Genetic Code Expansion and Reprogramming.Chemical reviews · 2024Review
- Evolution of Pyrrolysyl-tRNA Synthetase: From Methanogenesis to Genetic Code Expansion.Chemical reviews · 2024Review
- Truncation-Free Genetic Code Expansion with Tetrazine Amino Acids for Quantitative Protein Ligations.Bioconjugate chemistry · 2023Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 1 country.
Savanna Avila-CrumpDepartment of Biochemistry and Biophysics, 2011 Agricultural and Life Sciences, Oregon State University, Corvallis, Oregon 97331, United States.
Marcus L HemshornDepartment of Biochemistry and Biophysics, 2011 Agricultural and Life Sciences, Oregon State University, Corvallis, Oregon 97331, United States.
Chloe M JonesBiochemistry and Molecular Biophysics Graduate Group, University of Pennsylvania, 3700 Hamilton Walk, Philadelphia, Pennsylvania 19104, United States.
Lea MbengiDepartment of Chemistry, Portland State University, P.O. Box 751, Portland, Oregon 97207, United States.
Kyle MeyerDepartment of Chemistry, Portland State University, P.O. Box 751, Portland, Oregon 97207, United States.
Joshua A GriffisDepartment of Biochemistry and Biophysics, 2011 Agricultural and Life Sciences, Oregon State University, Corvallis, Oregon 97331, United States.
Subhashis JanaDepartment of Biochemistry and Biophysics, 2011 Agricultural and Life Sciences, Oregon State University, Corvallis, Oregon 97331, United States.
Grace E PetrinaDepartment of Biochemistry and Biophysics, 2011 Agricultural and Life Sciences, Oregon State University, Corvallis, Oregon 97331, United States.
Vinayak V PagarDepartment of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States.
P Andrew KarplusDepartment of Biochemistry and Biophysics, 2011 Agricultural and Life Sciences, Oregon State University, Corvallis, Oregon 97331, United States.
E James PeterssonDepartment of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104, United States.
John J PeronaDepartment of Chemistry, Portland State University, P.O. Box 751, Portland, Oregon 97207, United States.ORCID 0000-0002-2219-3021
Ryan A MehlDepartment of Biochemistry and Biophysics, 2011 Agricultural and Life Sciences, Oregon State University, Corvallis, Oregon 97331, United States.ORCID 0000-0003-2932-4941
Richard B CooleyDepartment of Biochemistry and Biophysics, 2011 Agricultural and Life Sciences, Oregon State University, Corvallis, Oregon 97331, United States.ORCID 0000-0003-3928-2757
Oregon State University · USPortland State University · USUniversity of Pennsylvania · US
Funding
Medicinal Chemistry CoreU19NS110456 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI ROBERT H MACH · 2019 to 2026
$44.1MThe GCE4All Center: Unleashing the Potential of Genetic Code Expansion for Biomedical ResearchRM1GM144227 · NIGMS · OREGON STATE UNIVERSITY · PI RYAN A MEHL · 2022 to 2026
$6.2MSTRUCTURAL BIOLOGY TRAINING PROGRAMT32GM008275 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI WAND, A. JOSHUA · 1988 to 2018
$6.0MStudying Aggregation in Neurodegenerative Disease Using Synthetic ProteinsR01NS103873 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI Ernest James Petersson · 2019 to 2026
$2.1MDevelopment of an improved core technology for efficient genetic code expansion in biomedical researchR01GM131168 · NIGMS · OREGON STATE UNIVERSITY · PI MEHL, RYAN A · 2019 to 2021
$1.1MOrbitrap Elite with ETDS10OD020111 · OD · OREGON STATE UNIVERSITY · PI MAIER, CLAUDIA S · 2015 to 2015
$600kNIGMS NIH HHS R01 GM131168NIGMS NIH HHS RM1 GM144227NIGMS NIH HHS T32 GM008275NIH HHS S10 OD020111NINDS NIH HHS R01 NS103873NINDS NIH HHS U19 NS110456
Abstract
Genetic code expansion (GCE) technologies commonly use the pyrrolysyl-tRNA synthetase (PylRS)/tRNA
Indexed as
Amino AcidsAmino Acyl-tRNA SynthetasesHEK293 CellsHumansLysineMethanosarcinaRNA, TransferTyrosineAmino AcidsAmino Acyl-tRNA SynthetasesLysineRNA, TransferTyrosine
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.