Evidence map›Paper›PMID 36383259›Full record

ArticleJournal of neurology2023

Italian version of the Rasch-Built Overall Amyotrophic Lateral Sclerosis Disability Scale (ROADS): validation and longitudinal performance.

Andrea Fortuna, Daniele Sabbatini, Annachiara Frigo, Luca Bello, Francesca Calvi, Lorenzo Blasi, Giulia Gianferrari, Ilaria Martinelli, Giacomo Minicuci, Elena Pegoraro and 2 more

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In one paragraph

Article in Journal of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Andrea FortunaDepartment of Neurosciences, Neuromuscular Center, University of Padova, 35128, Padua, Italy.
Daniele SabbatiniDepartment of Neurosciences, University of Padova, Padua, Italy.
Annachiara FrigoUnit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic and Vascular Sciences, University of Padova, Padua, Italy.
Luca BelloDepartment of Neurosciences, Neuromuscular Center, University of Padova, 35128, Padua, Italy.
Francesca CalviDepartment of Neurosciences, Neuromuscular Center, University of Padova, 35128, Padua, Italy.
Lorenzo BlasiDepartment of Neurosciences, Neuromuscular Center, University of Padova, 35128, Padua, Italy.
Giulia GianferrariDepartment of Neuroscience, Neurology Unit, S. Agostino Estense Hospital, AziendaOspedalieroUniversitaria di Modena, Modena, Italy.
Ilaria MartinelliDepartment of Neuroscience, Neurology Unit, S. Agostino Estense Hospital, AziendaOspedalieroUniversitaria di Modena, Modena, Italy.
Giacomo MinicuciNeuromuscular Center, S. Bortolo Hospital, Vicenza, Italy.
Elena PegoraroDepartment of Neurosciences, Neuromuscular Center, University of Padova, 35128, Padua, Italy.
Jessica MandrioliNeuromuscular Center, S. Bortolo Hospital, Vicenza, Italy.
Gianni SorarùDepartment of Neurosciences, Neuromuscular Center, University of Padova, 35128, Padua, Italy. gianni.soraru@unipd.it.ORCID http://orcid.org/0000-0001-9691-6328

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo validate an Italian version of the Rasch-Built Overall ALS Disability Scale (ROADS) in a broad population of patients and assess its longitudinal performance over time.

methods270 ALS patients referring to the Motor Neuron Disease Clinic of the University of Padova and Modena (Italy) accepted to compile the Italian version of the ROADS and results were correlated with the ALSFRSr and ALSAQ-40 scores, FVC values, and creatinine or albumin blood levels. To verify test-retest reliability, patients were asked to fill in a second copy of the scale within 5-7 days. Thirty-nine patients compiled a further copy of questionnaire during the follow up visit (after 133 days on average) which allowed us a longitudinal assessment of the scale.

resultsWe found a good external construct validity between ROADS and either ALSFRS-R (correlation coefficient = 0.85) or ALSAQ-40 (correlation coefficient = - 0.84). Test-retest reliability was excellent with a concordance-correlation coefficient of 0.93. Yet, we observed a significant correlation between changes over time of the ROADS normalised sum score (- 2.18 point loss per month) and those of both the ALSFRS-R (positive correlation; Rho = 0.64, p ≤ 0.0001) or the ALSAQ-40 (negative correlation; Rho = - 0.60, p = 0.014).

conclusionsThe Italian version of ROADS proved to be a reliable marker to monitor overall disability in ALS patients. Further studies are necessary to assess its longitudinal performance.

Indexed as

Amyotrophic Lateral SclerosisMotor Neuron DiseaseActivities of Daily LivingHumansItalyReproducibility of ResultsSurveys and QuestionnairesALSALSFRS-RItalianROADSScaleValidation

Identifiers

PMID36383259
PMCPMC9971085

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.