Evidence map›Paper›PMID 36383195›Full record

ArticleThe Journal of cell biology2022

Letting go: Dishevelled phase separation recruits Axin to stabilize β-catenin.

Rachel L Babcock, Kevin Pruitt

Abstract readComment
In one paragraph

Article in The Journal of cell biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Phase separation in cancer at a glance.Journal of translational medicine · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Rachel L BabcockImmunology and Molecular Microbiology, Texas Tech University Health Sciences Center, Lubbock, TX.ORCID 0000-0002-1848-5494
Kevin PruittImmunology and Molecular Microbiology, Texas Tech University Health Sciences Center, Lubbock, TX.ORCID 0000-0002-6932-042X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dishevelled exerts a molecular force that guides cell fate, but how it does so remains enigmatic. In this issue, Kang et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202205069) show Dvl2 undergoes liquid-liquid phase separation to stabilize β-catenin by pulling Axin into its biomolecular condensate at the plasma membrane.

Indexed as

Axin Proteinbeta CateninDishevelled ProteinsAxin Signaling ComplexHumansWnt Signaling PathwayAxin ProteinAxin Signaling Complexbeta CateninDishevelled Proteins

Identifiers

PMID36383195
PMCPMC9674272

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.