ArticleScience advances2022
WiChR, a highly potassium-selective channelrhodopsin for low-light one- and two-photon inhibition of excitable cells.
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Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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46citing papers in PubMed
7.8field-weighted citation impact, top 1% of its field
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Who cites it
46 citing papers in PubMed, 81 citations in OpenAlex.
- Experimentally informed, quantitative photocycle model of the light-gated potassium channel WiChR.Biophysical journal · 2026Article
- Channel gating in bacteriorhodopsin-like channelrhodopsins with contrasting KBiophysical journal · 2026Article
- Theoretical analysis of low-power optogenetic suppression of action potentials in human ventricular cardiomyocytes expressed with potassium-selective channelrhodopsins.Scientific reports · 2026Article
- Stabilized Ion Selectivity Corrects Activation Drift in Kalium Channelrhodopsins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Technical development of two-photon optogenetic stimulation and its potential application to brain-machine interfaces.Neurophotonics · 2026Review
- Roadmap for direct and indirect translation of optogenetics into discoveries and therapies for humans.Nature neuroscience · 2025Review
- Optogenetic silencing by combining a rhodopsin cyclase with an engineered cGMP-gated potassium channel.Science advances · 2025Article
- Apusomonad rhodopsins: A new family of ultraviolet to blue light-absorbing rhodopsin channels.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Computational Simulations Show Proof-of-Concept for Optogenetic Suppression of Ectopic Activity in Cardiac Stem Cell Therapy.Cardiovascular engineering and technology · 2025Article
- Two Decades of Optogenetic Tools: A Retrospective and a Look Ahead.Advanced genetics (Hoboken, N.J.) · 2025Review
- A genetically defined pontine nucleus essential for ingestion in mice.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- CryoRhodopsins: A comprehensive characterization of a group of microbial rhodopsins from cold environments.Science advances · 2025Article
- Pore-Opening and Ion-Conduction Mechanism in Channelrhodopsins C1C2, ChR2, and iChloC by Computational Electrophysiology and Constant-pH Simulations.Journal of chemical information and modeling · 2025Article
- Article
- Optogenetic engineering for ion channel modulation.Current opinion in chemical biology · 2025Review
- Structural insights into light-gating of potassium-selective channelrhodopsin.Nature communications · 2025Article
- Suppression of epileptic seizures by transcranial activation of KNature communications · 2025Article
- Review
- Monitoring and modulating cardiac bioelectricity: from Einthoven to end-user.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Review
- Multimodal evaluation of network activity and optogenetic interventions in human hippocampal slices.Nature neuroscience · 2024Article
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 4 countries.
Johannes VierockInstitut für Biologie, Experimentelle Biophysik, Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0001-7368-5539
Enrico ShiewerInstitut für Biologie, Experimentelle Biophysik, Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0001-7913-5597
Christiane GrimmWavefront Engineering Microscopy Group, Photonics Department, Institut de la Vision, Sorbonne Université, INSERM, CNRS, Paris, France.ORCID 0000-0002-2407-6152
Andrey RozenbergFaculty of Biology, Technion-Israel Institute of Technology, Haifa 32000, Israel.ORCID 0000-0001-9534-2297
I-Wen ChenWavefront Engineering Microscopy Group, Photonics Department, Institut de la Vision, Sorbonne Université, INSERM, CNRS, Paris, France.ORCID 0000-0003-0598-7230
Linda TillertNeuroscience Research Center, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0001-7497-018X
Alejandro G Castro ScaliseInstitut für Biologie, Experimentelle Biophysik, Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-6397-0392
Marilù CasiniInstitute for Experimental Cardiovascular Medicine, University Heart Center Freiburg · Bad Krozingen, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.
Sandra AugustinInstitut für Biologie, Experimentelle Biophysik, Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0002-5959-9690
Dimitrii TaneseWavefront Engineering Microscopy Group, Photonics Department, Institut de la Vision, Sorbonne Université, INSERM, CNRS, Paris, France.ORCID 0000-0002-9696-962X
Benoît C ForgetWavefront Engineering Microscopy Group, Photonics Department, Institut de la Vision, Sorbonne Université, INSERM, CNRS, Paris, France.ORCID 0000-0001-7334-8428
Rémi PeyronnetInstitute for Experimental Cardiovascular Medicine, University Heart Center Freiburg · Bad Krozingen, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.ORCID 0000-0002-5708-6410
Franziska Schneider-WarmeInstitute for Experimental Cardiovascular Medicine, University Heart Center Freiburg · Bad Krozingen, Medical Center and Faculty of Medicine, University of Freiburg, Freiburg im Breisgau, Germany.ORCID 0000-0002-5873-9436
Valentina EmilianiWavefront Engineering Microscopy Group, Photonics Department, Institut de la Vision, Sorbonne Université, INSERM, CNRS, Paris, France.
Oded BéjàFaculty of Biology, Technion-Israel Institute of Technology, Haifa 32000, Israel.ORCID 0000-0001-6629-0192
Peter HegemannInstitut für Biologie, Experimentelle Biophysik, Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0003-3589-6452
Centre National de la Recherche Scientifique · FRHumboldt-Universität zu Berlin · DEUniversity Medical Center Freiburg · DETechnion – Israel Institute of Technology · ILCharité - Universitätsmedizin Berlin · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
The electric excitability of muscle, heart, and brain tissue relies on the precise interplay of Na
Indexed as
LightPotassiumChannelrhodopsinsNeuronsOptogeneticsSodiumChannelrhodopsinsPotassiumSodium
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What OpenQuestion holds
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LicenceCC BY-NC
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.