ArticleJournal of neurophysiology2022
The role of aperiodic spectral slope in event-related potentials and cognition among children with and without attention deficit hyperactivity disorder.
Article in Journal of neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review of Aperiodic Neural Activity in Clinical Investigations.The European journal of neuroscience · 2025Pooled it
- The effects of transcranial random noise stimulation on excitation/inhibition balance in ADHD.NeuroImage. Clinical · 2026Trial
- A pilot safety and tolerability study of scanning ultrasound as a neuromodulation therapy in Alzheimer's disease.Brain communications · 2025Trial
- Inattention in Pediatric Attention-Deficit/Hyperactivity Disorder and Anxiety: Neurophysiological Evidence for Distinct and Overlapping Cognitive Mechanisms.Journal of attention disorders · 2026Article
- Relating ADHD to the aperiodic component of the EEG signal in both males and females across development.Developmental cognitive neuroscience · 2026Article
- Beyond Neural Noise: Critical Dynamics Predict Slower Reaction Times in Adults With and Without ADHD.bioRxiv : the preprint server for biology · 2026Article
- The association between reaction time variability and social problems in children with ADHD: support for the role of attentional fluctuations in social interactions.European child & adolescent psychiatry · 2025Article
- Differential representations of spatial location by aperiodic and alpha oscillatory activity in working memory.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Metacontrol-related aperiodic neural activity decreases but strategic adjustment thereof increases from childhood to adulthood.Scientific reports · 2025Article
- BSD: A Bayesian Framework for Parametric Models of Neural Spectra.The European journal of neuroscience · 2025Article
- Task-induced 1/f slope modulation as a paradigm-independent marker of cognitive control in multiple sclerosis.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Cognitive load-dependent effects of HD-tDCS on the executive vigilance decrement: insights from aperiodic EEG activity.Frontiers in cognition · 2025Article
- EEG aperiodic dynamics from early through late childhood: Associations with ADHD, cognition, and development.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- Subthalamic nucleus input-output dynamics are correlated with Parkinson's burden and treatment efficacy.NPJ Parkinson's disease · 2024Article
- Neurophysiological avenues to better conceptualizing adaptive cognition.Communications biology · 2024Article
- Test-retest reliability of spectral parameterization by 1/f characterization using SpecParam.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Changes in electrophysiological aperiodic activity during cognitive control in Parkinson's disease.Brain communications · 2024Article
- The spectral slope as a marker of excitation/inhibition ratio and cognitive functioning in multiple sclerosis.Human brain mapping · 2023Article
- Preterm birth accelerates the maturation of spontaneous and resting activity in the visual cortex.bioRxiv : the preprint server for biology · 2023Article
- Preterm birth accelerates the maturation of spontaneous and resting activity in the visual cortex.Frontiers in integrative neuroscience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Aperiodic spectral slope is a measure of spontaneous neural oscillatory activity that is believed to support regulation of brain responses to environmental stimuli. Compared to typically developing (TD) control participants, children with attention deficit hyperactivity disorder (ADHD) have been shown to have flatter aperiodic spectral slope at rest as well as attenuated event-related potential (ERP) amplitudes in response to environmental stimuli. A small body of research suggests that aperiodic slope may also explain differences in behavioral responses. In this study, we examine associations between prestimulus aperiodic slope, stimulus characteristics, environmental demands, and neural as well as behavioral responses to these stimuli. Furthermore, we evaluate whether ADHD diagnostic status moderates these associations. Seventy-nine children with ADHD and 27 TD school-age children completed two visual ERP experiments with predictable alternating presentations of task-relevant and task-irrelevant stimuli. Aperiodic slope was extracted from prestimulus time windows. Prestimulus aperiodic slope was steeper for the TD relative to ADHD group, driven by task-relevant rather than task-irrelevant stimuli. For both groups, the aperiodic slope was steeper during a task with lower cognitive demand and before trials in which they responded correctly. Aperiodic slope did not mediate the association between ADHD diagnosis and attenuated P300 amplitude. The aperiodic spectral slope is dynamic and changes in anticipation of varying stimulus categories to support performance. The aperiodic slope and P300 amplitude reflect distinct cognitive processes. Background neural oscillations, captured via aperiodic slope, support cognitive behavioral control and should be included in etiological models of ADHD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.