Evidence map›Paper›PMID 36382899›Full record

ArticleJournal of neurophysiology2022

The brain landscape of the two-hit model of posttraumatic stress disorder.

Lisa M James, Brian E Engdahl, Peka Christova, Scott M Lewis, Apostolos P Georgopoulos

Abstract read
In one paragraph

Article in Journal of neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lisa M JamesThe PTSD Research Group, Brain Sciences Center, Department of Veterans Affairs Health Care System, Minneapolis, Minnesota.ORCID 0000-0001-9021-0690
Brian E EngdahlThe PTSD Research Group, Brain Sciences Center, Department of Veterans Affairs Health Care System, Minneapolis, Minnesota.
Peka ChristovaThe PTSD Research Group, Brain Sciences Center, Department of Veterans Affairs Health Care System, Minneapolis, Minnesota.
Scott M LewisThe PTSD Research Group, Brain Sciences Center, Department of Veterans Affairs Health Care System, Minneapolis, Minnesota.
Apostolos P GeorgopoulosThe PTSD Research Group, Brain Sciences Center, Department of Veterans Affairs Health Care System, Minneapolis, Minnesota.ORCID 0000-0003-4412-725X

Funding

U.S. Department of Veterans Affairs (VA) Service Directed Research Grant 3105
6 · The paper itself

Abstract

The neurophysiological mechanisms underlying the development of posttraumatic stress disorder (PTSD) are poorly understood. Here we test a proposal that PTSD symptoms reflect fixed, highly correlated neural networks resulting from massive engagement of sensory inputs and the sequential involvement of those projections to limbic areas. Three-tesla functional magnetic resonance imaging (fMRI) data were acquired at rest in 15 veterans diagnosed with PTSD and 21 healthy control veterans from which zero-lag cross correlations between 50 brain areas (

Indexed as

Stress Disorders, Post-TraumaticVeteransBrainBrain MappingHumansMagnetic Resonance Imagingfunctional magnetic resonance imaginghypercorrelationlimbicneural networkposttraumatic stress disorder

Identifiers

PMID36382899
PMCPMC9744638

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.