ArticleeLife2022
Binary and analog variation of synapses between cortical pyramidal neurons.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A connectome and analysis of the adulteLife · 2020Pooled it
- Synaptic-state-dependent plasticity routes learning signals in recurrent circuits.bioRxiv : the preprint server for biology · 2026Article
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- Structure, disorder, and dynamics in task-trained recurrent neural circuits.bioRxiv : the preprint server for biology · 2026Article
- Physical contact reveals a hidden layer of cortical architecture.bioRxiv : the preprint server for biology · 2026Article
- Cellular and subcellular specialization enables biology-constrained deep learning.Cell reports · 2026Article
- Synaptic-resolution connectomics: towards large brains and connectomic screening.Nature reviews. Neuroscience · 2026Review
- Convergent information flows explain recurring firing patterns in cerebral cortex.Nature neuroscience · 2026Article
- Article
- Frenet-Serret Frame-Based Decomposition for Part Segmentation of 3-D Curvilinear Structures.IEEE transactions on medical imaging · 2025Article
- An anatomical substrate of credit assignment in reinforcement learning.bioRxiv : the preprint server for biology · 2025Article
- Slow Transition to Low-Dimensional Chaos in Heavy-Tailed Recurrent Neural Networks.bioRxiv : the preprint server for biology · 2025Article
- Article
- A multisynaptic spiking neuron for simultaneously encoding spatiotemporal dynamics.Nature communications · 2025Article
- Hebb's Vision: The Structural Underpinnings of Hebbian Assemblies.bioRxiv : the preprint server for biology · 2025Article
- VSOT: volume-surface optimization for accurate ultrastructure analysis of dendritic spines.Bioinformatics (Oxford, England) · 2025Article
- CAVE: Connectome Annotation Versioning Engine.Nature methods · 2025Article
- Article
- Article
- Connectivity of single neurons classifies cell subtypes in mouse brains.Nature methods · 2025Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
37 authors.
Funding
Abstract
Learning from experience depends at least in part on changes in neuronal connections. We present the largest map of connectivity to date between cortical neurons of a defined type (layer 2/3 [L2/3] pyramidal cells in mouse primary visual cortex), which was enabled by automated analysis of serial section electron microscopy images with improved handling of image defects (250 × 140 × 90 μm
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.