Evidence map›Paper›PMID 36382882›Full record

ArticleProtein science : a publication of the Protein Society2022

Phage-assisted, active site-directed ligand evolution of a potent and selective histone deacetylase 8 inhibitor.

Jared S Morse, Yan J Sheng, Joshua Trae Hampton, Lauralee D Sylvain, Sukant Das, Yugendar R Alugubelli, Peng-Hsun Chase Chen, Kai S Yang, Shiqing Xu, Carol A Fierke and 1 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein science : a publication of the Protein Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Incorporation of Butyryl-Lysine into Phage-Displayed Peptide Libraries.Methods in molecular biology (Clifton, N.J.) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jared S MorseTexas A&M Drug Discovery Laboratory, Department of Chemistry, Texas A&M University, Texas, USA.ORCID 0000-0002-4654-9379
Yan J ShengTexas A&M Drug Discovery Laboratory, Department of Chemistry, Texas A&M University, Texas, USA.
Joshua Trae HamptonTexas A&M Drug Discovery Laboratory, Department of Chemistry, Texas A&M University, Texas, USA.ORCID 0000-0001-5562-162X
Lauralee D SylvainTexas A&M Drug Discovery Laboratory, Department of Chemistry, Texas A&M University, Texas, USA.
Sukant DasTexas A&M Drug Discovery Laboratory, Department of Chemistry, Texas A&M University, Texas, USA.
Yugendar R AlugubelliTexas A&M Drug Discovery Laboratory, Department of Chemistry, Texas A&M University, Texas, USA.
Peng-Hsun Chase ChenTexas A&M Drug Discovery Laboratory, Department of Chemistry, Texas A&M University, Texas, USA.ORCID 0000-0001-9822-6398
Kai S YangTexas A&M Drug Discovery Laboratory, Department of Chemistry, Texas A&M University, Texas, USA.ORCID 0000-0002-1890-4169
Shiqing XuTexas A&M Drug Discovery Laboratory, Department of Chemistry, Texas A&M University, Texas, USA.ORCID 0000-0001-6260-9290
Carol A FierkeDepartment of Biochemistry, Brandeis University, Waltham, Massachusetts, USA.ORCID 0000-0002-1481-0579
Wenshe Ray LiuTexas A&M Drug Discovery Laboratory, Department of Chemistry, Texas A&M University, Texas, USA.ORCID 0000-0002-7078-6534
Texas A&M University · USBrandeis University · USTexas Medical Center · US

Funding

Use of the Noncanonical Amino Acid Mutagenesis Technique in Combination with Other Approaches to Study Functions of Posttranslational Lysine Modifications in ProteinsR35GM145351 · NIGMS · TEXAS A&M UNIVERSITY · PI Wenshe Ray Liu · 2022 to 2026
$2.6M
NIGMS NIH HHS R35 GM145351
6 · The paper itself

Abstract

Phage-assisted, active site-directed ligand evolution (PADLE) is a recently developed technique that uses an amber codon-encoded noncanonical amino acid (ncAA) as an anchor to direct phage-displayed peptides to a target for an enhanced ligand identification process. 2-Amino-8-oxodecanoic acid (Aoda) is a ketone-containing ncAA residue in the macrocyclic peptide natural product apicidin that is a pan-inhibitor of Zn

Indexed as

BacteriophagesHistone Deacetylase InhibitorsAmino AcidsCatalytic DomainCodon, TerminatorEscherichia coliHistone DeacetylasesKetonesLigandsPeptidesAmino AcidsCodon, TerminatorHistone Deacetylase InhibitorsHistone DeacetylasesKetonesLigandsPeptidesamber suppressionHDAC8PADLEphage-assisted active site-directed ligand evolutionphage display

Identifiers

PMID36382882
PMCPMC9703592
OpenAlexW4309164388

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.