Evidence map›Paper›PMID 36382769›Full record

ArticleMagnetic resonance in medicine2023

Fractional myocardial blood volume by ferumoxytol-enhanced MRI: Estimation of ischemic burden.

Caroline M Colbert, John J Hollowed, Dylan N Nguyen, Sandra Duarte-Vogel, Magnus Dahlbom, Peng Hu, Kim-Lien Nguyen

Open access · greenAbstract read
In one paragraph

Article in Magnetic resonance in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Ferumoxytol-enhanced cardiovascular magnetic resonance imaging: applications and technical advances.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Caroline M ColbertPhysics and Biology in Medicine Graduate Program, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
John J HollowedDivision of Cardiology, David Geffen School of Medicine at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, California, USA.
Dylan N NguyenDepartment of Computer Science and Engineering, Samueli School of Engineering at UCLA, Los Angeles, California, USA.
Sandra Duarte-VogelDivision of Laboratory Animal Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Magnus DahlbomPhysics and Biology in Medicine Graduate Program, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Peng HuPhysics and Biology in Medicine Graduate Program, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Kim-Lien NguyenPhysics and Biology in Medicine Graduate Program, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.ORCID 0000-0002-8854-2976
University of California, Los Angeles · USSamueli Institute · USVA Greater Los Angeles Healthcare System · US

Funding

Ferumoxytol-Enhanced Cardiac MRI for Ischemic Heart DiseaseR01HL148182 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NGUYEN, KIM-LIEN T · 2020 to 2024
$3.8M
Tailoring Stress Cardiac MRI for Women with Ischemic Heart DiseaseI01CX001901 · VA · VA GREATER LOS ANGELES HEALTHCARE SYSTEM · PI NGUYEN, KIM-LIEN T · 2019 to 2025
–
CSRD VA I01 CX001901NHLBI NIH HHS R01 HL148182
6 · The paper itself

Abstract

purposeTo investigate model-fitted fractional myocardial blood volume (fMBV) derived from ferumoxytol-enhanced MRI as a measure of myocardial tissue hypoperfusion at rest.

methodsWe artificially induced moderate to severe focal coronary stenosis in the left anterior descending artery of 19 swine by percutaneous delivery of a 3D-printed coronary implant. Using the MOLLI pulse sequence, we acquired T

resultsIschemic myocardial segments showed a mean MRI-fMBV of 11.72 ± 3.00%, compared with 8.23 ± 2.12% in remote segments and 8.38 ± 2.23% in normal segments. Ischemic segments showed a restricted transvascular water-exchange rate (k

conclusionsModel-fitted fMBV derived from ferumoxytol-enhanced MRI can distinguish regions of ischemia from remote myocardium in a swine model of myocardial hypoperfusion.

Indexed as

Coronary Artery DiseaseMyocardial IschemiaAnimalsBlood VolumeFerrosoferric OxideIschemiaMagnetic Resonance ImagingMyocardiumSwineWaterFerrosoferric OxideWaterblood volumeiron-based and other contrast agentsischemic heart diseasemyocardial perfusionparametric mapping

Identifiers

PMID36382769
PMCPMC10166270
OpenAlexW4309154428

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.