ArticlePsychotherapy and psychosomatics2022
Operational Definitions of Treatment Response and Remission in Obsessive-Compulsive Disorder Capture Meaningful Improvements in Everyday Life.
Article in Psychotherapy and psychosomatics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Does early non-improvement predict treatment failure in pharmacotherapy for obsessive-compulsive disorder? A diagnostic test accuracy meta-analysis with individual participant data.Psychological medicine · 2025Pooled it
- Enhancing readiness for exposure and response prevention in obsessive compulsive disorder: ketogenic metabolic therapy as a candidate readiness adjunct.Frontiers in psychology · 2026Review
- A randomized clinical trial of app cognitive behavior therapy vs. HealthWatch for obsessive compulsive disorder.NPJ digital medicine · 2025Article
- The timing of symptom change and early treatment response in a self-guided digital treatment for obsessive-compulsive disorder.The British journal of clinical psychology · 2025Article
- Altered Striatal Functional Gradients in Obsessive-Compulsive Disorder.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Altered striatal functional gradients in obsessive-compulsive disorder.medRxiv : the preprint server for health sciences · 2025Article
- Association Between Polygenic Risk and Symptom Severity Change After Cognitive Behavioral Therapy for Obsessive-Compulsive Disorder.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2025Article
- Minimal clinically important difference in obsessive-compulsive disorder.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- MAGNITUDE: Transcranial Magnetic Stimulation for Treatment-Resistant Obsessive-Compulsive Disorder: A Randomized Sham-Controlled Phase II Trial Protocol.Brain sciences · 2025Article
- The minimal important difference in obsessive-compulsive disorder: An analysis of double-blind SSRI trials in adults.European psychiatry : the journal of the Association of European Psychiatrists · 2024Article
- Longitudinal study of gut microbiome in obsessive-compulsive disorder.Brain and behavior · 2023Article
- Things that make you go Hmm: Myths and misconceptions within cognitive-behavioral treatment of obsessive-compulsive disorder.Journal of obsessive-compulsive and related disorders · 2023Article
- High treatment resistance is associated with lower performance in the Stroop test in patients with obsessive-compulsive disorder.Frontiers in psychiatry · 2023Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 2 countries.
Funding
Abstract
introductionThe operational definitions of treatment response, partial response, and remission in obsessive-compulsive disorder (OCD) are widely used in clinical trials and regular practice. However, the clinimetric sensitivity of these definitions, that is, whether they identify patients that experience meaningful changes in their everyday life, remains unexplored.
objectiveThe objective was to examine the clinimetric sensitivity of the operational definitions of treatment response, partial response, and remission in children and adults with OCD.
methodsPre- and post-treatment data from five clinical trials and three cohort studies of children and adults with OCD (n = 1,528; 55.3% children, 61.1% female) were pooled. We compared (1) responders, partial responders, and non-responders and (2) remitters and non-remitters on self-reported OCD symptoms, clinician-rated general functioning, and self-reported quality of life. Remission was also evaluated against post-treatment diagnostic interviews.
resultsResponders and remitters experienced large improvements across validators. Responders had greater improvements than partial responders and non-responders on self-reported OCD symptoms (Cohen's d 0.65-1.13), clinician-rated functioning (Cohen's d 0.53-1.03), and self-reported quality of life (Cohen's d 0.63-0.73). Few meaningful differences emerged between partial responders and non-responders. Remitters had better outcomes across most validators than non-remitters. Remission criteria corresponded well with absence of post-treatment diagnosis (sensitivity/specificity: 93%/83%). Using both the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) and the Clinical Global Impression Scale yielded more conservative results and more robust changes across validators, compared to only using the Y-BOCS.
conclusionsThe current definitions of treatment response and remission capture meaningful improvements in the everyday life of individuals with OCD, whereas the concept of partial response has dubious clinimetric sensitivity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.