Evidence map›Paper›PMID 36382539›Full record

ArticleJournal of Crohn's & colitis2023

Endoscopic Recurrence or Anastomotic Wound Healing Phenomenon after Ileocolic Resection for Crohn's Disease: The Challenges of Accurate Endoscopic Scoring.

Eline M L van der Does de Willebois, Marjolijn Duijvestein, Karin A Wasmann, Geert R A M D'Haens, Jarmila D W van der Bilt, Marco W Mundt, Roel Hompes, Manon van der Vlugt, Christianne J Buskens, Willem A Bemelman

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Crohn's & colitis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
  6. Article
  7. How Reliable Is Endoscopic Scoring of Postoperative Recurrence in Crohn Disease?: A Systematic Review and Meta-Analysis.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2024
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Eline M L van der Does de WilleboisDepartment of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Marjolijn DuijvesteinDepartment of Gastroenterology and Hepatology, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Karin A WasmannDepartment of Surgery, UMC Utrecht, Utrecht, the Netherlands.
Geert R A M D'HaensAmsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands.
Jarmila D W van der BiltDepartment of Surgery, Flevoziekenhuis, Almere, the Netherlands.
Marco W MundtDepartment of Gastroenterology, Flevoziekenhuis, Almere, the Netherlands.
Roel HompesDepartment of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Manon van der VlugtAmsterdam Gastroenterology Endocrinology Metabolism, Amsterdam, the Netherlands.
Christianne J BuskensDepartment of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Willem A BemelmanDepartment of Surgery, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Amsterdam University Medical Centers · NLFlevoziekenhuis · NLRadboud University Medical Center · NLUniversity of Amsterdam · NLUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsAdequate endoscopic scoring in Crohn's disease [CD] is crucial, as it dictates the need for initiating postoperative medical therapy and is utilized as an outcome parameter in clinical trials. Here we aimed to observe anastomotic wound healing in relation to endoscopic scoring of both inverted and everted stapled lines in side-to-side anastomoses.

methodsTwo prospective patient cohorts were included: ileocolic resection [ICR] for CD, and right-sided colon resection for colorectal cancer [CRC]. Videos taken during colonoscopy 6 months postoperatively were evaluated. The Simplified Endoscopic Activity Score for Crohn's Disease and modified Rutgeerts score were determined. The primary outcome was the presence of ulcerations in CD patients on both the inverted and the everted stapled lines. Secondary outcomes were the presence of anastomotic ulcerations in CRC patients and the number of cases having ulcerations exclusively at the inverted stapled line.

resultsOf the 82 patients included in the CD cohort, ulcerations were present in 63/82 [76.8%] at the inverted- vs 1/71 [1.4%] at the everted stapled line. Likewise in the CRC cohort, ulcerations were present in 4/6 [67.7%] at the inverted vs 0/6 [0%] at the everted stapled line. In total, 27% of the 63 patients in the CD cohort had ulcerations exclusively on the inverted stapled line.

conclusionInverted stapled lines heal with ulcerations, whereas everted stapled lines heal without any ulcerations, in both CD and non-CD patients. The abnormalities at the inverted stapled line might interfere with endoscopic scoring of recurrence, with potentially an impact on patients' quality of life and on healthcare costs if postoperative treatment is initiated incorrectly.

Indexed as

Crohn DiseaseAnastomosis, SurgicalColonColonoscopyHumansIleumProspective StudiesQuality of LifeRecurrenceRetrospective Studiesanastomotic wound healingCrohn’s diseaseendoscopic recurrenceileocolic resection

Identifiers

PMID36382539
PMCPMC10155740
OpenAlexW4309162687

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.