ArticleChemical science2022
A light-gated regulation of the reaction site by a cucurbit[7]uril macrocycle.
Article in Chemical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Photoswitchable Catalysis by a Self-Assembled Molecular Cage.Journal of the American Chemical Society · 2024Article
- Controlling DNA nanodevices with light-switchable buffers.Chemical communications (Cambridge, England) · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Competitive inhibition can be overcome by increasing the amount of catalyst in the reaction mixture. Here we present a pseudorotaxane system that circumvents this rule. A merocyanine inhibitor linked with the substrate obstructs the binding of the macrocyclic catalyst at the electrophilic reaction site preventing catalysis. Under UV light merocyanine is converted to the spiropyran form, losing its inhibition properties, thereby allowing the catalyst to bind the reaction center and promote the reaction. Moreover, when more than one nucleophile is present in the reaction mixture, the pseudorotaxane can scavenge a selected nucleophile and change the final product ratio. This work is a step forward in the development of new types of regulation in catalytic systems with remote control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.