Evidence map›Paper›PMID 36382148›Full record

ArticleRSC advances2022

Development of novel isatin thiazolyl-pyrazoline hybrids as promising antimicrobials in MDR pathogens.

Tarfah Al-Warhi, Diaaeldin M Elimam, Zainab M Elsayed, Marwa M Abdel-Aziz, Raed M Maklad, Ahmed A Al-Karmalawy, Kamyar Afarinkia, Mohammed A S Abourehab, Hatem A Abdel-Aziz, Wagdy M Eldehna

Abstract read
In one paragraph

Article in RSC advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
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  9. Identification of sulphonamide-tetheredJournal of enzyme inhibition and medicinal chemistry · 2023
    Article
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  11. Article
  12. Current status ofRSC advances · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tarfah Al-WarhiDepartment of Chemistry, College of Science, Princess Nourah bint Abdulrahman University P.O. Box 84428 Riyadh 11671 Saudi Arabia.
Diaaeldin M ElimamDepartment of Pharmacognosy, Faculty of Pharmacy, Kafrelsheikh University Kafrelsheikh Egypt.
Zainab M ElsayedScientific Research and Innovation Support Unit, Faculty of Pharmacy, Kafrelsheikh University Kafrelsheikh Egypt.
Marwa M Abdel-AzizThe Regional Center for Mycology & Biotechnology, Al-Azhar University Cairo Egypt.
Raed M MakladDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University Kafrelsheikh 33516 Egypt wagdy2000@gmail.com.ORCID https://orcid.org/0000-0002-5219-4842
Ahmed A Al-KarmalawyPharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University 6th of October City Giza 12566 Egypt.ORCID https://orcid.org/0000-0002-8173-6073
Kamyar AfarinkiaInstitute of Cancer Therapeutics, University of Bradford Bradford BD7 1DP UK.ORCID https://orcid.org/0000-0003-2819-4364
Mohammed A S AbourehabDepartment of Pharmaceutics, Faculty of Pharmacy, Umm Al-Qura University Makkah 21955 Saudi Arabia.
Hatem A Abdel-AzizDepartment of Applied Organic Chemistry, National Research Center P.O. Box 12622, Dokki Giza Egypt.
Wagdy M EldehnaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University Kafrelsheikh 33516 Egypt wagdy2000@gmail.com.ORCID https://orcid.org/0000-0001-6996-4017

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microbial Multidrug Resistance (MDR) is an emerging global crisis. Derivatization of natural or synthetic scaffolds is among the most reliable strategies to search for and obtain novel antimicrobial agents for the treatment of MDR infections. Here, we successfully manipulated the synthetically flexible isatin moieties to synthesize 22 thiazolyl-pyrazolines hybrids, and assessed their potential antimicrobial activities

Identifiers

PMID36382148
PMCPMC9629177

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.