Evidence map›Paper›PMID 36382086›Full record

ArticleCancer research communications2022

A ketogenic diet in combination with gemcitabine increases survival in pancreatic cancer KPC mice.

Natalia E Cortez, Cecilia Rodriguez Lanzi, Brian V Hong, Jihao Xu, Fangyi Wang, Shuai Chen, Jon J Ramsey, Matthew G Pontifex, Michael Müller, David Vauzour and 4 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Cancer research communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 28 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Review
  14. The Interplay between the Gut and Ketogenic Diets in Health and Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Natalia E CortezDepartment of Nutrition, University of California, Davis. One Shields Ave, Davis, CA, 95616, USA.
Cecilia Rodriguez LanziDepartment of Nutrition, University of California, Davis. One Shields Ave, Davis, CA, 95616, USA.
Brian V HongDepartment of Nutrition, University of California, Davis. One Shields Ave, Davis, CA, 95616, USA.
Jihao XuDepartment of Microbiology and Molecular Genetics, University of California Davis, Davis, CA 95616, USA.
Fangyi WangDepartment of Animal Science, University of California, Davis. One Shields Ave, Davis, CA, 95616, USA.
Shuai ChenDivision of Biostatistics, Department of public Health Sciences, University of California, Davis. One Shields Ave, Davis, CA, 95616, USA.
Jon J RamseyDepartment of Molecular Biosciences, University of California Davis, Davis, CA 95616, USA.
Matthew G PontifexNorwich Medical School, Biomedical Research Centre, University of East Anglia, Norwich NR4 7TJ, United Kingdom.
Michael MüllerNorwich Medical School, Biomedical Research Centre, University of East Anglia, Norwich NR4 7TJ, United Kingdom.
David VauzourNorwich Medical School, Biomedical Research Centre, University of East Anglia, Norwich NR4 7TJ, United Kingdom.
Payam VahmaniDepartment of Animal Science, University of California, Davis. One Shields Ave, Davis, CA, 95616, USA.
Chang-Il HwangDepartment of Microbiology and Molecular Genetics, University of California Davis, Davis, CA 95616, USA.
Karen MatsukumaDepartment of Pathology and Laboratory Medicine, Sacramento, CA, 95817, USA.
Gerardo G MackenzieDepartment of Nutrition, University of California, Davis. One Shields Ave, Davis, CA, 95616, USA.
University of California, Davis · USUniversity of East Anglia · GBSacramento City College · US

Funding

Staff InvestigatorsP30CA093373 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI Gina M Dayton · 2002 to 2026
$84.9M
NCI NIH HHS P30 CA093373
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) continues to be a major health problem. A ketogenic diet (KD), characterized by a very low carbohydrate and high fat composition, has gained attention for its anti-tumor potential. We evaluated the effect and mechanisms of feeding a strict KD alone or in combination with gemcitabine in the autochthonous LSL-Kras

Indexed as

Carcinoma, Pancreatic DuctalDiet, KetogenicPancreatic NeoplasmsAnimalsFemaleGemcitabineMaleMiceGemcitabineERK and AKT signaling pathwaysgemcitabineKetogenic dietLipid metabolismmicrobiomepancreatic cancerpancreatic ductal adenocarcinoma

Identifiers

PMID36382086
PMCPMC9648418
OpenAlexW4290803961

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.