Evidence map›Paper›PMID 36381756›Full record

ArticleCureus2022

L-Asparaginase-Induced Continuous Hyperglycemia With Type 1 Diabetes-Related Antibodies and HLA Genotypes: A Case Study.

Yasuhisa Furuta, Shigeru Yatoh, Hitoshi Iwasaki, Yoko Sugano, Motohiro Sekiya, Hiroaki Suzuki, Hitoshi Shimano

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Yasuhisa FurutaDepartment of Endocrinology and Metabolism, Faculty of Medicine, University of Tsukuba, Tsukuba, JPN.
Shigeru YatohDepartment of Endocrinology and Metabolism, Faculty of Medicine, University of Tsukuba, Tsukuba, JPN.
Hitoshi IwasakiDepartment of Endocrinology and Metabolism, Faculty of Medicine, University of Tsukuba, Tsukuba, JPN.
Yoko SuganoDepartment of Endocrinology and Metabolism, Faculty of Medicine, University of Tsukuba, Tsukuba, JPN.
Motohiro SekiyaDepartment of Endocrinology and Metabolism, Faculty of Medicine, University of Tsukuba, Tsukuba, JPN.
Hiroaki SuzukiDepartment of Endocrinology and Metabolism, Faculty of Medicine, University of Tsukuba, Tsukuba, JPN.
Hitoshi ShimanoDepartment of Endocrinology and Metabolism, Faculty of Medicine, University of Tsukuba, Tsukuba, JPN.
University of Tsukuba · JPJA Toride Medical Center · JPJapan Agency for Medical Research and Development · JPTsukuba International University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 19-year-old male presented with fatigue and dyspnea on exertion. He was diagnosed with acute T-cell lymphoblastic leukemia. After following the Group for Research on Adult Acute Lymphoblastic Leukemia (GRAALL) 2003 protocol that incorporates L-asparaginase (L-Asp) treatment, blood glucose levels became elevated for more than one year and insulin secretion was depleted. Anti-glutamic acid decarboxylase (GAD) and anti-islet antigen 2 (IA-2) antibody levels were both positive, which is rare. The patient's HLA genotype was sensitive for type 1 diabetes. L-Asp can cause transient hyperglycemia as a side effect. However, cases with the anti-GAD antibody have not been reported in L-Asp-induced diabetes. In summary, L-Asp-induced continuous hyperglycemia might be associated with a type 1 diabetes-related HLA genotype through elevations of anti-GAD and anti-IA-2 antibodies.

Indexed as

acute lymphoblastic leukemia (all)anti-gad antibodyhlal-asparaginasetype 1 diabetes mellitus (t1d)

Identifiers

PMID36381756
PMCPMC9639571
OpenAlexW4303648312

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.