ArticleACS catalysis2021
Copper-Catalyzed Aminoheteroarylation of Unactivated Alkenes through Distal Heteroaryl Migration.
Article in ACS catalysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Copper-Catalyzed Three-Component Selective 1,4-Amino Oxygenation of 1,3-Dienes.Angewandte Chemie (International ed. in English) · 2026Article
- Copper-Catalyzed Asymmetric Amino Lactonization of Alkenes: Direct Access to Enantioenriched 1,2-Alkylamino Alcohol Derivatives.Journal of the American Chemical Society · 2026Article
- Three-component synthesis of β-thio tertiary alkylamines from simple alkenes via SScience advances · 2026Article
- Three-Component Catalytic Amino Etherification of Alkenes: Enabled by Silyl Ether-Promoted C-O Coupling.ACS catalysis · 2025Article
- Copper-Catalyzed Selective Amino-alkoxycarbonylation of Unactivated Alkenes with CO.Journal of the American Chemical Society · 2025Article
- A General Amino-(Hetero)arylation of Simple Olefins with (Hetero)aryl Sulfonamides Enabled by anACS catalysis · 2025Article
- Copper-Catalyzed 1,4-Aminohydroxylation and Aminothiolation of 1,3-Dienes by Carbonyl-Assisted Migration.Chem catalysis · 2024Article
- Radical-Mediated Trifunctionalization Reactions.Molecules (Basel, Switzerland) · 2024Review
- Recent Advances in 1,2-Amino(hetero)arylation of Alkenes.Chemistry, an Asian journal · 2022Review
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Authors and funding
3 authors.
Funding
Abstract
We report a copper-catalyzed aminoheteroarylation of unactivated alkenes to access valuable heteroarylethylamine motif. The developed reaction features a copper-catalyzed intermolecular electrophilic amination of the alkenes followed by a migratory heteroarylation. The method applies on alcohol-, amide-, and ether-containing alkenes, overcoming the common requirement of a hydroxyl motif in previous migratory difunctionalization reactions. This reaction is effective for the introduction of diverse aliphatic amines and has good functional group tolerance, which is particularly useful for richly functionalized heteroarenes. This migration-involved reaction was found well suited as a powerful ring expansion approach for the construction of medium-sized rings that are in great demand in medicinal chemistry.
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Registered trials
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