ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2022
The relationship between Alzheimer's-related brain atrophy patterns and sleep macro-architecture.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 13 citations in OpenAlex.
- Association of self-reported hearing loss and tinnitus with brain structure and cognitive function: a population-based cross-sectional analysis from the Study of Health in Pomerania (SHIP).Alzheimer's research & therapy · 2026Article
- Associations among sleep quality, cognitive decline, and Alzheimer's disease pathology in older adults: A longitudinal study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Wavelet Entropy Analysis of EEG Signals During Wake and Sleep in Patients with Alzheimer's Disease: A Pilot Study.Neuropsychiatric disease and treatment · 2026Article
- Lower slow wave sleep and rapid eye movement sleep are associated with brain atrophy of Alzheimer's disease-vulnerable regions.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Anxious-depressive symptoms and sleep disturbances across the Alzheimer disease spectrum.Nature. Mental health · 2025Article
- Sleep macro-architecture, nocturnal hypoxemia, and Alzheimer's disease-related MRI patterns among diverse older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Lower slow wave sleep and rapid eye-movement sleep are associated with brain atrophy of AD-vulnerable regions.bioRxiv : the preprint server for biology · 2025Article
- Modified life's essential 8 mediate the correlation between dietary index for gut microbiota and sleep disorders.Frontiers in nutrition · 2025Article
- Association of spermidine blood levels with microstructure of sleep-implications from a population-based study.GeroScience · 2024Article
- The relationship between Alzheimer's-related brain atrophy patterns and sleep macro-architecture.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- Sleep, Cognitive Dysfunction, and Daily Living in Chinese Older Adults: Evidence From the CHARLS (2011 to 2020).Alzheimer disease and associated disordersArticle
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
Introduction: Sleep is increasingly recognized as a major risk factor for neurodegenerative disorders such as Alzheimer's disease (AD). Methods: Using an magnetic resonance imaging (MRI)-based AD score based on clinical data from the Alzheimer's Disease Neuroimaging Initiative 1 (ADNI1) case-control cohort, we investigated the associations between polysomnography-based sleep macro-architecture and AD-related brain atrophy patterns in 712 pre-symptomatic, healthy subjects from the population-based Study of Health in Pomerania. Results: We identified a robust inverse association between slow-wave sleep and the AD marker (estimate: -0.019; 95% confidence interval: -0.03 to -0.0076; false discovery rate [FDR] = 0.0041), as well as with gray matter (GM) thicknesses in typical individual cortical AD-signature regions. No effects were identified regarding rapid eye movement or non-rapid eye movement (NREM) stage 2 sleep, and NREM stage 1 was positively associated with GM thickness, mainly in the prefrontal cortical regions. Discussion: There is a cross-sectional relationship between AD-related neurodegenerative patterns and the proportion of sleep spent in slow-wave sleep.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.