Evidence map›Paper›PMID 36381323›Full record

ArticleAmerican journal of cancer research2022

Targetable vulnerability of deregulated FOXM1/PLK1 signaling axis in diffuse large B cell lymphoma.

Fang Yu, Hua He, Loretta J Nastoupil, Zijun Y Xu-Monette, Ky Pham, Yong Liang, Guang Chen, Nathan H Fowler, C Cameron Yin, Dongfeng Tan and 5 more

Open access · greenAbstract read
In one paragraph

Article in American journal of cancer research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 2 countries.

Fang YuDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.
Hua HeDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.
Loretta J NastoupilDepartment of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center Houston, TX, USA.
Zijun Y Xu-MonetteDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.
Ky PhamDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.
Yong LiangDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.
Guang ChenDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.
Nathan H FowlerDepartment of Lymphoma and Myeloma, The University of Texas MD Anderson Cancer Center Houston, TX, USA.
C Cameron YinDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.
Dongfeng TanDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.
Yaling YangDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.
Shimin HuDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.
Ken H YoungDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.
Lan V PhamDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.
M James YouDepartment of Hematopathology, The University of Texas MD Anderson Cancer Center Houston, TX, USA.
The University of Texas MD Anderson Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

FOXM1 is a transcription factor that controls cell cycle regulation, cell proliferation, and differentiation. Overexpression of FOXM1 has been implicated in various cancer types. However, the activation status and functional significance of FOXM1 in diffuse large B cell lymphoma (DLBCL) have not been well investigated. Using proteomic approaches, we discovered that the protein expression levels of FOXM1 and PLK1 were positively correlated in DLBCL cell lines and primary DLBCL. Expression levels of

Indexed as

DLBCLFOXM1PLK1therapeutic potential

Identifiers

PMID36381323
PMCPMC9641390
OpenAlexW4309247126

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.