Evidence map›Paper›PMID 36381279›Full record

ArticleIranian journal of biotechnology2022

Ectopic expression of OCT4B1 Decreases Fertility Rate and Changes Sperm Parameters in Transgenic Mice.

Marzieh Naseri, Ehsan Ranaei Pirmardan, Seyed Javad Mowla, Mehdi Shamsara, Mansoreh Movahedin, Saeideh Nouri, Karim Nayernia, Maryam Kabir Salmani, Maryam Shahali

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In one paragraph

Article in Iranian journal of biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Marzieh NaseriOncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Ehsan Ranaei PirmardanDepartment of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Seyed Javad MowlaDepartment of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran.
Mehdi ShamsaraNational Research Center for Transgenic Mouse, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
Mansoreh MovahedinAnatomical Sciences Department, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Saeideh NouriAnatomical Sciences Department, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Karim NayerniaInstitute of Molecular Medicine & Cell Therapy (mmct), Düsseldorf, Germany.
Maryam Kabir SalmaniDepartment of Stem Cell and Regenerative Medicine, Institute of Medical Biotechnology, National Institute of Genetic Engineering & Biotechnology (NIGEB), Tehran, Iran.
Maryam ShahaliDepartment of Production, Research and Production Complex, Pasteur Institute of Iran, Tehran, Iran.
Tarbiat Modares University · IRNational Institute of Genetic Engineering and Biotechnology · IRIran University of Medical Sciences · IRPasteur Institute of Iran · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The octamer-binding transcription factor-4 (OCT4) is known as an established important regulator of pluripotency, as well as a genetic "master switch" in the self-renewal of embryonic stem and germ cells. Objectives: The present study developed a transgenic mouse model containing an Material and Methods: The Results: The results demonstrated the changes in sperm morphology, as well as a statistically significant decrease in the other sperm parameters (count, viability, and motility) and fertility rate (p<0.05) in the transgenic mice compared with the control group. The assessment of the cause of the embryonic stem cell (ESC) death following transfection revealed a significant reduction in the endogenous OCT4 expression at both mRNA and protein levels in the transfected mESCs compared to the control ones. Conclusion: In general, the

Indexed as

Embryonic Stem CellsInfertilityOCT4B1Sperm ParametersTransgenic Mice

Identifiers

PMID36381279
PMCPMC9618016
OpenAlexW4309247812

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.