Evidence map›Paper›PMID 36381237›Full record

ArticleCancer research communications2022

Evaluation of the DLL3-targeting antibody-drug conjugate rovalpituzumab tesirine in preclinical models of neuroblastoma.

Kateryna Krytska, Colleen E Casey, Jennifer Pogoriler, Daniel Martinez, Komal S Rathi, Alvin Farrel, Esther R Berko, Matthew Tsang, Renata R Sano, Nathan Kendsersky and 7 more

Open access · goldAbstract read
In one paragraph

Article in Cancer research communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Kateryna KrytskaDivision of Oncology and Center for Childhood Cancer Research; Children's Hospital of Philadelphia, Philadelphia, PA, 19104.
Colleen E CaseyDivision of Oncology and Center for Childhood Cancer Research; Children's Hospital of Philadelphia, Philadelphia, PA, 19104.
Jennifer PogorilerDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104.
Daniel MartinezDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104.
Komal S RathiDivision of Oncology and Center for Childhood Cancer Research; Children's Hospital of Philadelphia, Philadelphia, PA, 19104.
Alvin FarrelDivision of Oncology and Center for Childhood Cancer Research; Children's Hospital of Philadelphia, Philadelphia, PA, 19104.
Esther R BerkoDivision of Oncology and Center for Childhood Cancer Research; Children's Hospital of Philadelphia, Philadelphia, PA, 19104.
Matthew TsangDivision of Oncology and Center for Childhood Cancer Research; Children's Hospital of Philadelphia, Philadelphia, PA, 19104.
Renata R SanoDivision of Oncology and Center for Childhood Cancer Research; Children's Hospital of Philadelphia, Philadelphia, PA, 19104.
Nathan KendserskyDivision of Oncology and Center for Childhood Cancer Research; Children's Hospital of Philadelphia, Philadelphia, PA, 19104.
Stephen W EricksonRTI International, Research Triangle Park, NC.
Beverly A TeicherNational Cancer Inst., Bethesda, MD.
Kumiko IsseAbbvie Stemcentrx, South San Francisco, CA.
Laura SaundersAbbvie Stemcentrx, South San Francisco, CA.
Malcolm A SmithNational Cancer Inst., Bethesda, MD.
John M MarisDivision of Oncology and Center for Childhood Cancer Research; Children's Hospital of Philadelphia, Philadelphia, PA, 19104.
Yael P MosséDivision of Oncology and Center for Childhood Cancer Research; Children's Hospital of Philadelphia, Philadelphia, PA, 19104.
Children's Hospital of Philadelphia · USChemoCentryx (United States) · USORCID · USUniversity of Pennsylvania · USRTI International · US

Funding

Discovering mechanisms of neuroblastoma tumorigenesis to improve patient outcomesR35CA220500 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI JOHN M MARIS · 2017 to 2026
$8.7M
NCI Pediatric In Vivo Testing Program: NeuroblastomaU01CA263957 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI MOSSE, YAEL P · 2021 to 2025
$3.5M
Pediatric Preclinical Testing ConsortiumU01CA199287 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI MARIS, JOHN M · 2015 to 2021
$2.1M
Credentialing Delta-like 3 (DLL3) as an oncoprotein and immunotherapeutic target in neuroblastomaF31CA239424 · NCI · UNIVERSITY OF PENNSYLVANIA · PI KENDSERSKY, NATHAN MICHAEL · 2020 to 2022
$121k
NCI NIH HHS F31 CA239424NCI NIH HHS R35 CA220500NCI NIH HHS U01 CA199287NCI NIH HHS U01 CA263957
6 · The paper itself

Abstract

Neuroblastomas have neuroendocrine features and often show similar gene expression patterns to small cell lung cancer including high expression of delta-like ligand 3 (

Indexed as

ImmunoconjugatesLung NeoplasmsNeuroblastomaSmall Cell Lung CarcinomaAntibodies, Monoclonal, HumanizedBenzodiazepinonesChildHumansIntracellular Signaling Peptides and ProteinsLigandsMembrane ProteinsAntibodies, Monoclonal, HumanizedBenzodiazepinonesDLL3 protein, humanImmunoconjugatesIntracellular Signaling Peptides and ProteinsLigandsMembrane Proteinsrovalpituzumab tesirine

Identifiers

PMID36381237
PMCPMC9648412
OpenAlexW4283586320

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.