Evidence map›Paper›PMID 36381158›Full record

ArticleCentral European journal of urology2022

Prospective long-term experience in the treatment of renal tumors with cryotherapy: follow-up with computed tomography scan and contrast-enhanced ultrasound.

Inés Laso-García, Fernando Arias-Fúnez, Marta Santiago-González, Enrique Sanz-Mayayo, Gema Duque-Ruiz, Manuel Hevia-Palacios, Victoria Gómez-Dos-Santos, Andreina Olavarria-Delgado, Ana Palomera-Rico, Francisco Javier Burgos-Revilla

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Central European journal of urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Inés Laso-GarcíaUrology Department, Ramón y Cajal University Hospital, Alcalá University, IRYCIS, Madrid, Spain.
Fernando Arias-FúnezUrology Department, Ramón y Cajal University Hospital, Alcalá University, IRYCIS, Madrid, Spain.
Marta Santiago-GonzálezUrology Department, Ramón y Cajal University Hospital, Alcalá University, IRYCIS, Madrid, Spain.
Enrique Sanz-MayayoUrology Department, Ramón y Cajal University Hospital, Alcalá University, IRYCIS, Madrid, Spain.
Gema Duque-RuizUrology Department, Ramón y Cajal University Hospital, Alcalá University, IRYCIS, Madrid, Spain.
Manuel Hevia-PalaciosUrology Department, Ramón y Cajal University Hospital, Alcalá University, IRYCIS, Madrid, Spain.
Victoria Gómez-Dos-SantosUrology Department, Ramón y Cajal University Hospital, Alcalá University, IRYCIS, Madrid, Spain.
Andreina Olavarria-DelgadoRadiology Department, Ramón y Cajal University Hospital, Alcalá University, IRYCIS, Madrid, Spain.
Ana Palomera-RicoRadiology Department, Ramón y Cajal University Hospital, Alcalá University, IRYCIS, Madrid, Spain.
Francisco Javier Burgos-RevillaUrology Department, Ramón y Cajal University Hospital, Alcalá University, IRYCIS, Madrid, Spain.
Instituto Ramón y Cajal de Investigación Sanitaria · ESInstituto Cajal · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The aim of this article was to evaluate the oncological results and safety of cryotherapy for the treatment of renal tumors. Material and methods: This study was a prospective review and follow-up of patients who underwent cryotherapy from January 2008 to May 2021. Cryotherapy was offered to patients with bilateral tumors, tumors in solitary kidneys, or comorbid patients. Follow-up consisted of a computed tomography (CT) scan and contrast-enhanced ultrasound (CEUS), with analysis of concordance (kappa index). Overall survival and kidney survival were analyzed (Kaplan-Meier). Results: Cryotherapy was performed 71 times in 67 patients. A total of 74.6% of patients were men. The mean age of patients was 69.7 years (standard deviation (SD) 11.3]. Mean follow-up was 52.7 months (SD 36.2). Mean tumor size was 26.2 mm (SD 7.6). 90% were cT1a, 10% cT1b stage. Type of access was open in 1 patient, laparoscopic in 8, percutaneous US-guided in 8 and percutaneous CT-guided in 54 patients. Biopsy was taken in 60 patients (84.5%) and consisted of renal cell carcinoma (22), oncocytoma (9), papillary carcinoma (4), angiomyolipoma (1), sarcoma (1), and non-conclusive (23).There were 22 complications such as pain in 2 patients, hematoma in 8 and 2 cases of bleeding, all resolved conservatively except for one case of bleeding which required embolization.Recurrences occurred in 16 cases (22.5%). Management was cryotherapy in 25%, radical nephrectomy in 31.3% and surveillance in 43.8%. Concordance between contrast-enhanced ultrasound and CT was 0.8 (excellent).Mean glomerular filtration did not change. One patient developed metastasis.No cancer-specific mortality was found. Overall survival at 12, 24 and 48 months was 98.5%, 96.8% and 76.9% respectively. Kidney survival at 12, 24 and 48 months was 97%, 93.5% and 93.5% respectively. Conclusions: Cryotherapy for renal tumors is a safe treatment for comorbid or solitary kidney patients, with rare major complications and good oncological outcome.

Indexed as

complicationscryotherapykidney cancerresultstreatment

Identifiers

PMID36381158
PMCPMC9628719
OpenAlexW4297128507

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.