Evidence map›Paper›PMID 36381011›Full record

ArticleJournal of the Endocrine Society2022

Prospective Analysis of Muscle Adiposity in Children With X-linked Hypophosphatemic Rickets vs Control Children.

Virginie Nguyen-Khac, Aurore Bonnet-Lebrun, Agnès Linglart, Marine de Tienda, Jugurtha Berkenou, Inès Mannes, Catherine Adamsbaum, Philippe Wicart, Wafa Skalli

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Virginie Nguyen-KhacAP-HP, Department of Pediatric Orthopedic Surgery, Hospital Necker-Enfants-Malades, 75015 Paris, France.ORCID https://orcid.org/0000-0002-4770-0413
Aurore Bonnet-LebrunENSAM, Institut de Biomécanique Humaine G. Charpark, Arts et Métiers, 75013 Paris, France.
Agnès LinglartAP-HP, Paris Saclay University, Reference Center for Rare Diseases of Calcium and Phosphate Metabolism, and Filière OSCAR, Endocrinology and Diabetes for Children, INSERM U1185, Bicêtre Paris-Saclay Hospital, Le Kremlin-Bicêtre, 94270 Paris, France.ORCID https://orcid.org/0000-0003-3455-002X
Marine de TiendaAP-HP, Department of Pediatric Orthopedic Surgery, Hospital Necker-Enfants-Malades, 75015 Paris, France.
Jugurtha BerkenouAP-HP, Paris Saclay University, Reference Center for Rare Diseases of Calcium and Phosphate Metabolism, and Filière OSCAR, Endocrinology and Diabetes for Children, INSERM U1185, Bicêtre Paris-Saclay Hospital, Le Kremlin-Bicêtre, 94270 Paris, France.
Inès MannesAP-HP, Paris Saclay University, Reference Center for Rare Diseases of Calcium and Phosphate Metabolism, and Filière OSCAR, Endocrinology and Diabetes for Children, INSERM U1185, Bicêtre Paris-Saclay Hospital, Le Kremlin-Bicêtre, 94270 Paris, France.
Catherine AdamsbaumAP-HP, Paris Saclay University, Reference Center for Rare Diseases of Calcium and Phosphate Metabolism, and Filière OSCAR, Endocrinology and Diabetes for Children, INSERM U1185, Bicêtre Paris-Saclay Hospital, Le Kremlin-Bicêtre, 94270 Paris, France.
Philippe WicartAP-HP, Department of Pediatric Orthopedic Surgery, Hospital Necker-Enfants-Malades, 75015 Paris, France.
Wafa SkalliENSAM, Institut de Biomécanique Humaine G. Charpark, Arts et Métiers, 75013 Paris, France.
Inserm · FRHôpital Necker-Enfants Malades · FRArts et Métiers · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Context: Children with X-linked hypophosphatemic (XLH) rickets have muscle weakness that severely impairs their function. Intermuscular and intramuscular adipose tissue (IMAT and intraMAT, respectively) may contribute to this muscle weakness. Objective: This work aimed to compare IMAT and intraMAT in XLH children vs typically developing (TD) children. Methods: A prospective, monocentric cohort study was conducted of XLH (n = 11; aged 10.3 years [6-17]) and TD children (n = 22; aged 10.2 years [5-15.5]). All children underwent magnetic resonance imaging of the lower limbs; IMAT and intraMAT percentages were calculated after manual contouring of each muscle of the thigh and the deep fascia at mid-thigh level. Results: XLH children were comparable in age but shorter and heavier than TD children ( Conclusion: Our results show that IMAT is higher in young children with XLH, independently of obesity and overweight. Further, these results will facilitate both the early prevention of functional and metabolic consequences of the increase in adipose tissue in XLH children.

Indexed as

IMATintraMATMRImuscle weaknessXLH rickets

Identifiers

PMID36381011
PMCPMC9642316
OpenAlexW4294586769

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.