Evidence map›Paper›PMID 36380886›Full record

ArticleNeurology. Clinical practice2022

Downbeat Nystagmus Is Abolished by Alcohol in Nonalcoholic Wernicke Encephalopathy.

Christoph Helmchen, Björn Machner, Janina von der Gablentz, Andreas Sprenger, David S Zee

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Clinical practice, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Christoph HelmchenDepartment of Neurology (CH, BM, JG, AS), University Hospital Schleswig Holstein, Lübeck; Center of Brain, Behavior and Metabolism (CH, BM, JG, AS), University of Lübeck; Institute of Psychology II (AS), University Lübeck, Germany; and Departments of Neurology (DSZ), Ophthalmology, Otolaryngology-Head and Neck Surgery, and Neuroscience, Division of Neuro-Visual and Vestibular Disorders, The Johns Hopkins Hospital, Baltimore.
Björn MachnerDepartment of Neurology (CH, BM, JG, AS), University Hospital Schleswig Holstein, Lübeck; Center of Brain, Behavior and Metabolism (CH, BM, JG, AS), University of Lübeck; Institute of Psychology II (AS), University Lübeck, Germany; and Departments of Neurology (DSZ), Ophthalmology, Otolaryngology-Head and Neck Surgery, and Neuroscience, Division of Neuro-Visual and Vestibular Disorders, The Johns Hopkins Hospital, Baltimore.ORCID 0000-0001-7981-2906
Janina von der GablentzDepartment of Neurology (CH, BM, JG, AS), University Hospital Schleswig Holstein, Lübeck; Center of Brain, Behavior and Metabolism (CH, BM, JG, AS), University of Lübeck; Institute of Psychology II (AS), University Lübeck, Germany; and Departments of Neurology (DSZ), Ophthalmology, Otolaryngology-Head and Neck Surgery, and Neuroscience, Division of Neuro-Visual and Vestibular Disorders, The Johns Hopkins Hospital, Baltimore.
Andreas SprengerDepartment of Neurology (CH, BM, JG, AS), University Hospital Schleswig Holstein, Lübeck; Center of Brain, Behavior and Metabolism (CH, BM, JG, AS), University of Lübeck; Institute of Psychology II (AS), University Lübeck, Germany; and Departments of Neurology (DSZ), Ophthalmology, Otolaryngology-Head and Neck Surgery, and Neuroscience, Division of Neuro-Visual and Vestibular Disorders, The Johns Hopkins Hospital, Baltimore.ORCID 0000-0001-9255-7911
David S ZeeDepartment of Neurology (CH, BM, JG, AS), University Hospital Schleswig Holstein, Lübeck; Center of Brain, Behavior and Metabolism (CH, BM, JG, AS), University of Lübeck; Institute of Psychology II (AS), University Lübeck, Germany; and Departments of Neurology (DSZ), Ophthalmology, Otolaryngology-Head and Neck Surgery, and Neuroscience, Division of Neuro-Visual and Vestibular Disorders, The Johns Hopkins Hospital, Baltimore.ORCID 0000-0003-3909-2494
University of Lübeck · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: Lesions of the cerebellar flocculus cause enduring downbeat nystagmus (DBN) with unrelenting oscillopsia. Unlike most patients with DBN, the flocculus is structurally spared in nonalcoholic Wernicke encephalopathy (nWE) with chronic DBN. The objective was to study the effects of alcohol in nWE. Methods: We recorded eye movements of a unique patient with nWE under controlled alcohol consumption who said his oscillopsia disappeared with a few drinks of alcohol. Results: His DBN was markedly diminished by alcohol (by 77.4%), although he remained alert with normal saccades. Discussion: This striking observation may be caused by the differential effect of alcohol on the perihypoglossal complex and the paramedian tract neurons, which control the level of activity in the flocculus, with opposite (inhibition and excitation, respectively) effects. The finding suggests new ideas about the treatment and pathophysiology of DBN with a structurally intact cerebellum.

Identifiers

PMID36380886
PMCPMC9647809
OpenAlexW3208313582

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.