ArticleACS ES&T water2022
Nationwide Trends in COVID-19 Cases and SARS-CoV-2 RNA Wastewater Concentrations in the United States.
Article in ACS ES&T water, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The trial behind it
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Who cites it
42 citing papers in PubMed.
- Correlations between Wastewater Concentrations of Influenza A and Respiratory Syncytial Viruses and Clinical Laboratory Testing and Hospitalization Data, California, USA.Emerging infectious diseases · 2026Article
- Digital CRISPR-based diagnostics for quantification of Candida auris and resistance mutations.Nature biomedical engineering · 2026Article
- Long-term wastewater surveillance of SARS-CoV-2: a 5.5-year study reveals correlation with public health indicators and early warning potential during and after the pandemic.Frontiers in microbiology · 2026Article
- Article
- Evaluation of wastewater SARS-CoV-2 surveillance for monitoring COVID-19 trends and early warning in Sweden, 2023-2024.PloS one · 2026Article
- Coupling wastewater-based epidemiology with data-driven machine learning for managing public health risks.Risk analysis : an official publication of the Society for Risk Analysis · 2025Article
- Long term assessment of SARS-CoV-2 in wastewater and the transition to evaluate additional viral targets.The Science of the total environment · 2025Article
- Application of joinpoint regression to SARS-CoV-2 wastewater-based epidemiology in Las Vegas, Nevada, USA.Epidemiology and infection · 2025Article
- Operationalizing SARS-CoV-2 wastewater monitoring to assess traveler health in Las Vegas, Nevada, USA.IJID regions · 2025Article
- Statistical Relationship Between Wastewater Data and Case Notifications for COVID-19 Surveillance in the United States From 2020 to 2023: Bayesian Hierarchical Modeling Approach.JMIR public health and surveillance · 2025Article
- Wastewater Speaks: Evaluating SARS-CoV-2 Surveillance, Sampling Methods, and Seasonal Infection Trends on a University Campus.Microorganisms · 2025Article
- Variability of Clinical Metrics in Small Population Communities Drive Perceived Wastewater and Environmental Surveillance Data Quality: Ontario, Canada-Wide Study.ACS ES&T water · 2025Article
- Spatiotemporal Variability of the Pepper Mild Mottle Virus Biomarker in Wastewater.ACS ES&T water · 2025Article
- Association between SARS-CoV-2 in wastewater and COVID-19 hospitalizations in three countries, 2022-2024.Frontiers in public health · 2025Article
- Statistical analysis of three data sources for Covid-19 monitoring in Rhineland-Palatinate, Germany.Scientific reports · 2024Article
- Inferring COVID-19 testing and vaccination behavior from New Jersey testing data.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- SARS-CoV-2 surveillance in US wastewater: Leading indicators and data variability analysis in 2023-2024.PloS one · 2024Article
- Environmental monitoring of SARS-CoV-2 in the metropolitan area of Porto Alegre, Rio Grande do Sul (RS), Brazil.Environmental science and pollution research international · 2024Article
- Assessment of sewer connectivity in the United States and its implications for equity in wastewater-based epidemiology.PLOS global public health · 2024Article
- Article
Corrections and comments
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Authors and funding
20 authors.
Funding
Abstract
Wastewater-based epidemiology has emerged as a promising technology for population-level surveillance of COVID-19. In this study, we present results of a large nationwide SARS-CoV-2 wastewater monitoring system in the United States. We profile 55 locations with at least six months of sampling from April 2020 to May 2021. These locations represent more than 12 million individuals across 19 states. Samples were collected approximately weekly by wastewater treatment utilities as part of a regular wastewater surveillance service and analyzed for SARS-CoV-2 RNA concentrations. SARS-CoV-2 RNA concentrations were normalized to pepper mild mottle virus, an indicator of fecal matter in wastewater. We show that wastewater data reflect temporal and geographic trends in clinical COVID-19 cases and investigate the impact of normalization on correlations with case data within and across locations. We also provide key lessons learned from our broad-scale implementation of wastewater-based epidemiology, which can be used to inform wastewater-based epidemiology approaches for future emerging diseases. This work demonstrates that wastewater surveillance is a feasible approach for nationwide population-level monitoring of COVID-19 disease. With an evolving epidemic and effective vaccines against SARS-CoV-2, wastewater-based epidemiology can serve as a passive surveillance approach for detecting changing dynamics or resurgences of the virus.
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Registered trials
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