Evidence map›Paper›PMID 36380388›Full record

ArticleArchives of public health = Archives belges de sante publique2022

Survival analysis of patients with COVID-19 admitted at six hospitals in Uganda in 2021: a cohort study.

Asad Muyinda, Prossie M Ingabire, Susan Nakireka, Criscent Tumuhaise, Edith Namulema, Felix Bongomin, Agnes Napyo, Quraish Sserwanja, Rozen Ainembabazi, Ronald Olum and 11 more

Open access · goldAbstract read
In one paragraph

Article in Archives of public health = Archives belges de sante publique, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 13 institutions in 2 countries.

Asad Muyinda *Department of Medicine, Jinja Regional Referral Hospital, Jinja, Uganda.
Prossie M Ingabire *Department of Medicine, Nsambya Hospital, Kampala, Uganda.
Susan Nakireka *Department of medicine, Mengo Hospital, Kampala, Uganda.
Criscent TumuhaiseDepartment of Medicine, Our Lady Health of the Sick, Nkozi Hospital, Nkozi, Uganda.
Edith NamulemaCovid Task Force Institution, Mengo Hospital, Kampala, Uganda.
Felix BongominDepartment of Medical Microbiology, Gulu University, Gulu, Uganda.
Agnes NapyoDepartment of Community and Public Health, Busitema Universiy, Tororo, Uganda.
Quraish SserwanjaDepartment of Programmes, GOAL, Arkaweet Block 65 House No, 227, Khartoum, Sudan. qura661@gmail.com.ORCID https://orcid.org/0000-0003-0576-4627
Rozen AinembabaziDepartment of Medicine, Jaro Hospital, Wakiso, Uganda.
Ronald OlumDepartment of Medicine, Nsambya Hospital, Kampala, Uganda.
Ritah NantaleDepartment of Nursing, Busitema University, Tororo, Uganda.
Phillip AkunguruDepartment of Medicine, Moroto Hospital, Moroto, Uganda.
Derrick NomujuniDepartment of Medicine, Mulago Hospital, Kampala, Uganda.
William OlwitDepartment of Medicine, Nsambya Hospital, Kampala, Uganda.
Milton W MusabaDepartment of Obstetrics and Gynaecology, Mbale Regional Referral and Teaching Hospital, Mbale, Uganda.ORCID https://orcid.org/0000-0003-4145-4044
Bridget NamubiruDepartment of medicine, Mengo Hospital, Kampala, Uganda.
Pamela AolDepartment of Pediatrics, Lacor Hospital, Gulu, Uganda.
Peter A BabigumiraDepartment of Global Health Security, Ministry of Health, Kampala, Uganda.
Ian MunabiDepartment of Anatomy, Makerere University, Kampala, Uganda.
Sarah KiguliDepartment of Pediatrics and Child Health, Makerere University, Kampala, Uganda.
David MukunyaDepartment of Community and Public Health, Busitema Universiy, Tororo, Uganda.
Busitema University · UGMengo Hospital · UGNsambya Hospital · UGMakerere University · UGGulu University · UGJinja Hospital · UGMbale Hospital · UGMinistry of Health · UGMoroto Hospital · UGMulago Hospital · UGNile Valley University · SDNkozi Hospital · UGSt. Mary's Hospital Lacor · UG

Funding

Health Professions Education and training for strengthening the health system and services in UgandaR25TW011213 · FIC · MAKERERE UNIVERSITY COLLEGE OF HEALTH SCIENCES · PI KIGULI, SARAH · 2018 to 2022
$3.4M
FIC NIH HHS R25 TW011213
6 · The paper itself

Abstract

backgroundAssessing factors associated with mortality among COVID-19 patients could guide in developing context relevant interventions to mitigate the risk. The study aimed to describe mortality and associated factors among COVID-19 patients admitted at six health facilities in Uganda.

methodsWe reviewed medical records of patients admitted with COVID-19 between January 1st 2021 and December 31st 2021 in six hospitals in Uganda. Using Stata version 17.0, Kaplan Meier and Cox regression analyses were performed to describe the time to death and estimate associations between various exposures and time to death. Finally, accelerated failure time (AFT) models with a lognormal distribution were used to estimate corresponding survival time ratios.

resultsOut of the 1040 study participants, 234 (22.5%: 95%CI 12.9 to 36.2%) died. The mortality rate was 30.7 deaths per 1000 person days, 95% CI (26.9 to 35.0). The median survival time was 33 days, IQR (9-82). Factors associated with time to COVID-19 death included; age ≥ 60 years [adjusted hazard ratio (aHR) = 2.4, 95% CI: [1.7, 3.4]], having malaria test at admission [aHR = 2.0, 95% CI:[1.0, 3.9]], a COVID-19 severity score of severe/critical [aHR = 6.7, 95% CI:[1.5, 29.1]] and admission to a public hospital [aHR = 0.4, 95% CI:[0.3, 0.6]]. The survival time of patients aged 60 years or more is estimated to be 63% shorter than that of patients aged less than 60 years [adjusted time ratio (aTR) 0.37, 95% CI 0.24, 0.56]. The survival time of patients admitted in public hospitals was 2.5 times that of patients admitted in private hospitals [aTR 2.5 to 95%CI 1.6, 3.9]. Finally, patients with a severe or critical COVID-19 severity score had 87% shorter survival time than those with a mild score [aTR 0.13, 95% CI 0.03, 0.56].

conclusionIn-hospital mortality among COVID-19 patients was high. Factors associated with shorter survival; age ≥ 60 years, a COVID-19 severity score of severe or critical, and having malaria at admission. We therefore recommend close monitoring of COVID-19 patients that are elderly and also screening for malaria in COVID-19 admitted patients.

Indexed as

COVID-19SurvivalUganda

Identifiers

PMID36380388
PMCPMC9666944
OpenAlexW4309116012

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.