Evidence map›Paper›PMID 36380339›Full record

ReviewBMC oral health2022

Advances in novel therapeutic approaches for periodontal diseases.

Md Mahamudul Haque, Katherine Yerex, Anastasia Kelekis-Cholakis, Kangmin Duan

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BMC oral health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 3 pooled it
14.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 3 syntheses or guidelines pooled it, 99 citations in OpenAlex.

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  16. [Research Progress on Quorum Sensing-Regulated Oral Microbial Interaction Networks in Periodontitis].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Md Mahamudul HaqueDepartment of Oral Biology, University of Manitoba, Winnipeg, MB, Canada.
Katherine YerexSchool of Dental Hygiene, University of Manitoba, Winnipeg, MB, Canada.
Anastasia Kelekis-CholakisDepartment of Dental Diagnostic and Surgical Sciences, Rady Faculty of Health Sciences, Dr. Gerald Niznick College of Dentistry, University of Manitoba, Winnipeg, MB, Canada.
Kangmin DuanDepartment of Oral Biology, University of Manitoba, Winnipeg, MB, Canada. Kangmin.Duan@umanitoba.ca.ORCID 0000-0002-3016-786X
University of Manitoba · CAChildren's Hospital Research Institute of Manitoba · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontal diseases are pathological processes resulting from infections and inflammation affecting the periodontium or the tissue surrounding and supporting the teeth. Pathogenic bacteria living in complex biofilms initiate and perpetuate this disease in susceptible hosts. In some cases, broad-spectrum antibiotic therapy has been a treatment of choice to control bacterial infection. However, increasing antibiotic resistance among periodontal pathogens has become a significant challenge when treating periodontal diseases. Thanks to the improved understanding of the pathogenesis of periodontal disease, which involves the host immune response, and the importance of the human microbiome, the primary goal of periodontal therapy has shifted, in recent years, to the restoration of homeostasis in oral microbiota and its harmonious balance with the host periodontal tissues. This shift in therapeutic goals and the drug resistance challenge call for alternative approaches to antibiotic therapy that indiscriminately eliminate harmful or beneficial bacteria. In this review, we summarize the recent advancement of alternative methods and new compounds that offer promising potential for the treatment and prevention of periodontal disease. Agents that target biofilm formation, bacterial quorum-sensing systems and other virulence factors have been reviewed. New and exciting microbiome approaches, such as oral microbiota replacement therapy and probiotic therapy for periodontal disease, are also discussed.

Indexed as

Periodontal DiseasesQuorum SensingAnti-Bacterial AgentsBacteriaBiofilmsHumansAnti-Bacterial AgentsAntibiotic resistanceAnti-virulenceBiofilmsImmune modulatorsNovel therapeutic strategiesPeriodontal diseasesQuorum sensing inhibitors

Identifiers

PMID36380339
PMCPMC9664646
OpenAlexW4309514856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.