ArticleCardiovascular diabetology2022
Comparison of the effects of triglyceride variability and exposure estimate on clinical prognosis in diabetic patients.
Article in Cardiovascular diabetology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- LipiDecipher: A Structure-Oriented Analytical Framework for Interpretable Clinical Lipidomics.Metabolites · 2026Article
- Serum lipid profile as an indicator of disease severity in chronic liver disease: A hospital-based cross-sectional study.Bioinformation · 2026Article
- Recipient Periodic Fasting Promotes Osteogenesis of Implanted Mesenchymal Stromal Cell Aggregates and Safeguards Diabetic Mandibular Bone Regeneration.Stem cell reviews and reports · 2025Article
- Review
- Triglyceride-glucose index variability and risk of all-cause and cardiovascular mortality.Scientific reports · 2025Article
- Correlation analysis of the triglyceride-glucose index and related parameters in metabolic dysfunction-associated fatty liver disease.Scientific reports · 2025Article
- Metabolic syndrome parameters' variability and stroke incidence in hypertensive patients: evidence from a functional community cohort.Cardiovascular diabetology · 2024Article
- Article
- Effects of metabolic parameters' variability on cardiovascular outcomes in diabetic patients.Cardiovascular diabetology · 2023Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypertriglyceridemia is an important feature of dyslipidemia in type 1 and type 2 diabetic patients and associated with the development of atherosclerotic cardiovascular disease. Recently, variability of lipid profile has been suggested as a residual risk factor for cardiovascular disease. This study compared the clinical impact of serum triglyceride variability, and their cumulative exposure estimates on cardiovascular prognosis in diabetic patients.
methodsA total of 25,933 diabetic patients who had serum triglyceride levels measured at least 3 times and did not have underlying malignancy, myocardial infarction (MI), and stroke during the initial 3 years (modeling phase) were selected from three tertiary hospitals. They were divided into a high/low group depending on their coefficient of variation (CV) and cumulative exposure estimate (CEE). Incidence of major adverse event (MAE), a composite of all-cause death, MI, and stroke during the following 5 years were compared between groups by multivariable analysis after propensity score matching.
resultsAlthough there was a slight difference, both the high CV group and the high CEE group had a higher cardiovascular risk profile including male-dominance, smoking, alcohol, dyslipidemia, and chronic kidney disease compared to the low groups. After the propensity score matching, the high CV group showed higher MAE incidence compared to the low CV group (9.1% vs 7.7%, p = 0.01). In contrast, there was no significant difference of MAE incidence between the high CEE group and the low CEE group (8.6% vs 9.1%, p = 0.44). After the multivariable analysis with further adjustment for potential residual confounding factors, the high CV was suggested as an independent risk predictor for MAE (HR 1.19 [95% CI 1.03-1.37]).
conclusionVisit-to-visit variability of triglyceride rather than their cumulative exposure is more strongly related to the incidence of MAE in diabetic patients.
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