ArticleMolecular psychiatry2023
Mapping the cortico-striatal transcriptome in attention deficit hyperactivity disorder.
Article in Molecular psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Region-specific cortico-striatal transcriptomic remodeling following early postnatal dopaminergic disturbance.bioRxiv : the preprint server for biology · 2026Article
- Mapping ADHD Heterogeneity and Biotypes by Topological Deviations in Morphometric Similarity Networks.JAMA psychiatry · 2026Article
- Developmental trajectories of glutamate and the variable clinical course of ADHD in youth.Translational psychiatry · 2026Article
- Attention-deficit/hyperactivity disorder in India: epidemiology, diagnostic inequities, treatment gaps, and public mental health implications.Frontiers in psychiatry · 2026Review
- From genes to networks: neurobiological bases of neurodiversity across common developmental disorders.Frontiers in neuroscience · 2026Review
- Objective evaluation of attention-deficit/hyperactivity disorder medication effects using a load-cell-embedded chair in a simulated classroom.BMC psychiatry · 2025Article
- Unraveling Predominantly Inattentive ADHD (ADHD-PI): Insights from Proteomic Analysis of the Striatum of Thyroid Hormone-Responsive Protein (THRSP)-Overexpressing Mice.Molecular neurobiology · 2025Article
- The overlapping genetic architecture of psychiatric disorders and cortical brain structure.Nature. Mental health · 2025Article
- Integrative multi-omics data from early development to identify the genes and cell types underlying attention-deficit/hyperactivity disorder.BMC psychiatry · 2025Article
- Transformer-based structural connectivity networks for ADHD-related connectivity alterations.Communications medicine · 2025Article
- Mapping ADHD Heterogeneity and Biotypes through Topological Deviations in Morphometric Similarity Networks.medRxiv : the preprint server for health sciences · 2025Article
- Rare Variant Analyses in Ancestrally Diverse Cohorts Reveal Novel ADHD Risk Genes.medRxiv : the preprint server for health sciences · 2025Article
- Long-term, cell type-specific effects of prenatal stress on dorsal striatum and relevant behaviors in mice.bioRxiv : the preprint server for biology · 2024Article
- Novel pharmacological targets for GABAergic dysfunction in ADHD.Neuropharmacology · 2024Review
- Cortico-striatal differences in the epigenome in attention-deficit/ hyperactivity disorder.Translational psychiatry · 2024Article
- Attention-deficit/hyperactivity disorder.Nature reviews. Disease primers · 2024Review
- The effects of methylphenidate and atomoxetine on Drosophila brain at single-cell resolution and potential drug repurposing for ADHD treatment.Molecular psychiatry · 2024Article
- Population level multimodal neuroimaging correlates of attention-deficit hyperactivity disorder among children.Frontiers in neuroscience · 2023Article
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
Despite advances in identifying rare and common genetic variants conferring risk for ADHD, the lack of a transcriptomic understanding of cortico-striatal brain circuitry has stymied a molecular mechanistic understanding of this disorder. To address this gap, we mapped the transcriptome of the caudate nucleus and anterior cingulate cortex in post-mortem tissue from 60 individuals with and without ADHD. Significant differential expression of genes was found in the anterior cingulate cortex and, to a lesser extent, the caudate. Significant downregulation emerged of neurotransmitter gene pathways, particularly glutamatergic, in keeping with models that implicate these neurotransmitters in ADHD. Consistent with the genetic overlap between mental disorders, correlations were found between the cortico-striatal transcriptomic changes seen in ADHD and those seen in other neurodevelopmental and mood disorders. This transcriptomic evidence points to cortico-striatal neurotransmitter anomalies in the pathogenesis of ADHD, consistent with current models of the disorder.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.