ReviewJournal of muscle research and cell motility2023
Compensatory hemodynamic changes in response to central hypovolemia in humans: lower body negative pressure: updates and perspectives.
Review in Journal of muscle research and cell motility, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 14 citations in OpenAlex.
- Multiomic changes posthypovolemia in a lower body negative pressure model: unlocking new mechanisms or adding to the complexity?Physiological genomics · 2026Article
- Validation of a Wearable Photoplethysmography-Based Sensor for Compensatory Reserve Measurement Monitoring in Simulated Human Hemorrhage.Sensors (Basel, Switzerland) · 2026Article
- Ventilation-perfusion effects of negative-pressure ventilation: insights from an experimental rat model.Intensive care medicine experimental · 2026Article
- Reduced cerebral blood flow does not alter concurrent or post-intervention inhibitory control: evidence from a 3-h head-down tilt protocol in healthy young adults.Experimental brain research · 2026Article
- Optic nerve sheath diameter increases during 12Frontiers in physiology · 2026Article
- Dose-dependent reduction of optic nerve sheath diameter during graded lower body negative pressure in healthy adults of both sexes.Frontiers in network physiology · 2026Article
- Network physiology in space: vision and perspectives on exploring physiological networks during spaceflight for the benefit of life on earth.Frontiers in network physiology · 2026Article
- Internal jugular venous flow responses to graded lower body negative pressure: a sex-stratified analysis.Frontiers in physiology · 2026Article
- Repeatability of artificial gravity tolerance times.Frontiers in physiology · 2025Article
- A 10-min reduction in cerebral blood flow does not alter post-intervention executive function: evidence from lower-body negative pressure.Experimental brain research · 2024Article
- Effects of menstrual cycle on hemodynamic and autonomic responses to central hypovolemia.Frontiers in cardiovascular medicine · 2024Article
- Lessons learned from comparative and extreme physiology.Journal of muscle research and cell motility · 2023Article
- Association of gender with cardiovascular and autonomic responses to central hypovolemia.Frontiers in cardiovascular medicine · 2023Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Central hypovolemia is accompanied by hemodynamic compensatory responses. Understanding the complex systemic compensatory responses to altered hemodynamic patterns during conditions of central hypovolemia-as induced by standing up and/or lower body negative pressure (LBNP)-in humans are important. LBNP has been widely used to understand the integrated physiological responses, which occur during sit to stand tests (orthostasis), different levels of hemorrhages (different levels of LBNP simulate different amount of blood loss) as well as a countermeasure against the cephalad fluid shifts which are seen during spaceflight. Additionally, LBNP application (used singly or together with head up tilt, HUT) is useful in understanding the physiology of orthostatic intolerance. The role seasonal variations in hormonal, autonomic and circulatory state play in LBNP-induced hemodynamic responses and LBNP tolerance as well as sex-based differences during central hypovolemia and the adaptations to exercise training have been investigated using LBNP. The data generated from LBNP studies have been useful in developing better models for prediction of orthostatic tolerance and/or for developing countermeasures. This review examines how LBNP application influences coagulatory parameters and outlines the effects of temperature changes on LBNP responses. Finally, the review outlines how LBNP can be used as innovative teaching tool and for developing research capacities and interests of medical students and students from other disciplines such as mathematics and computational biology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.