Evidence map›Paper›PMID 36380060›Full record

ArticleScientific reports2022

Impacts of breast cancer and chemotherapy on gut microbiome, cognitive functioning, and mood relative to healthy controls.

Emily Bilenduke, John D Sterrett, Krista W Ranby, Virginia F Borges, Jim Grigsby, Alaina L Carr, Kristin Kilbourn, Christopher A Lowry

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

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  15. Specific microbiome patterns and their association with breast cancer: the intestinal microbiota as a potential biomarker and therapeutic strategy.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Emily BilendukeDepartment of Psychology, University of Colorado Denver, Denver, CO, USA. Emily.bilenduke@ucdenver.edu.
John D SterrettDepartment of Integrative Physiology and Center for Microbial Exploration, University of Colorado Boulder, Boulder, CO, USA.
Krista W RanbyDepartment of Psychology, University of Colorado Denver, Denver, CO, USA.
Virginia F BorgesDepartment of Medicine, University of Colorado School of Medicine, Aurora, CO, USA.
Jim GrigsbyDepartment of Psychology, University of Colorado Denver, Denver, CO, USA.
Alaina L CarrDepartment of Psychology, University of Colorado Denver, Denver, CO, USA.
Kristin KilbournDepartment of Psychology, University of Colorado Denver, Denver, CO, USA.
Christopher A LowryDepartment of Integrative Physiology and Center for Microbial Exploration, University of Colorado Boulder, Boulder, CO, USA.
University of Colorado Denver · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Colorado Boulder · US

Funding

Training Program in Cancer Population Science (CaPS)T32CA261787 · NCI · GEORGETOWN UNIVERSITY · PI Lucile L. Adams-Campbell, Suzanne C. O'Neill · 2021 to 2026
$1.1M
NCI NIH HHS T32 CA261787
6 · The paper itself

Abstract

Women diagnosed with breast cancer undergoing chemotherapy experience cognitive impairment, symptoms of anxiety and depression, and physical side effects including disruption in the diversity and community composition of the gut microbiome. To date, there is limited research exploring the associations among these specific challenges. The present cross-sectional study explored the associations of self-reported cognitive functioning, depression, and anxiety symptoms, and gut microbiome diversity and community composition in women who were diagnosed with and undergoing chemotherapy treatment for breast cancer (BC) compared to cancer-free healthy controls (HC). The BC group displayed higher rates of cognitive dysfunction (p < 0.001) and depressive symptoms (p < 0.05) relative to HC. There was a significant difference in microbiome community composition between BC and HC, particularly characterized by a decreased relative abundance of the mucin-degrading genus Akkermansia in BC compared to HC (p < 0.05). Association models identified significant associations among group, cognitive, depression, and microbiome variables (p < 0.001). Overall, the study identified that BC participants experienced significant differences in self-reported cognitive functioning, self-reported depression symptoms, microbiome community composition, and mucin-degrading bacteria of the gut-mucosal barrier, relative to HC. The present study is consistent with the hypothesis that gut microbiome community composition impacts a woman's experience with breast cancer and treatment suggesting that microbiome-based interventions have potential for improving quality of life outcomes in individuals with breast cancer.

Indexed as

Breast NeoplasmsGastrointestinal MicrobiomeCognitionCross-Sectional StudiesFemaleHumansMucinsQuality of LifeMucins

Identifiers

PMID36380060
PMCPMC9664046
OpenAlexW4309192274

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.