ArticleBiochemical genetics2023
Circ_MBNL3 Restrains Hepatocellular Carcinoma Progression by Sponging miR-873-5p to Release PHF2.
Article in Biochemical genetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- The role of histone demethylase PHF2 as a tumour suppressor in hepatocellular carcinoma by regulating SRXN1.Oncogenesis · 2026Article
- Exploring non-coding RNA mechanisms in hepatocellular carcinoma: implications for therapy and prognosis.Frontiers in immunology · 2024Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background Circular RNAs (circRNAs) have shown key regulatory roles in human malignancies. The working mechanism of circRNAs in hepatocellular carcinoma (HCC) remains to be elucidated. Methods Cell proliferation was analyzed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, 5-ethynyl-20-deoxyuridine (EdU) assay, and colony formation assay. Xenograft tumor model was established to analyze the role of circ_MBNL3 on tumor growth in vivo. Results Circ_MBNL3 expression was notably down-regulated in HCC tissues and cell lines. Circ_MBNL3 overexpression suppressed the proliferation, migration, and invasion and induced the apoptosis of HCC cells. miR-873-5p directly targeted the 3' untranslated region (3'UTR) of PHF2, and PHF2 was negatively regulated by miR-873-5p in HCC cells. miR-873-5p silencing-induced anti-tumor influences were largely reversed by the interference of PHF2 in HCC cells. Circ_MBNL3 restrained xenograft tumor growth in vivo. Conclusion Circ_MBNL3 restrained the proliferation, migration, and invasion and promoted the apoptosis of HCC cells depending on the regulation of miR-873-5p/PHF2 axis.
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Registered trials
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