ArticleNature communications2022
Specification of female germline by microRNA orchestrated auxin signaling in Arabidopsis.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Review
- The SbTDR gene is required for anther development and male fertility in Sorghum bicolor.Plant reproduction · 2026Article
- Molecular understanding of plant pollination, fertilization, seed development and protoplast regeneration.Science China. Life sciences · 2026Review
- From the MMC Specification to Endosperm Cellularization in Arabidopsis: A Developmental-Handover Framework for Seed Initiation.Plants (Basel, Switzerland) · 2026Review
- VPS13 has an important role in female germline development in Arabidopsis.The Plant journal : for cell and molecular biology · 2026Article
- SPOROCYTELESS/NOZZLE cooperates with MADS-domain transcription factors to regulate an auxin-dependent network controlling Megaspore-Mother-Cell differentiation.Nature communications · 2025Article
- A chaperonin BnaC01.CCT8 contributes to silique length and seed weight by affecting auxin and jasmonic acid signalling in Brassica napus.Plant biotechnology journal · 2025Article
- Cytological and genetic analyses of the seed number per silique locus BnSNSC09 in Brassica napus.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Sexual reproduction in land plants: an evolutionary perspective.Plant reproduction · 2025Review
- Advances in Small RNA Regulation of Female Gametophyte Development in Flowering Plants.Plants (Basel, Switzerland) · 2025Review
- Auxin Orchestrates Germ Cell Specification inInternational journal of molecular sciences · 2025Review
- Article
- The DNA methylation-demethylation balance prevents development of multiple megaspore mother cells in Arabidopsis.The Plant cell · 2025Article
- Regulation of cell cycle in plant gametes: when is the right time to divide?Development (Cambridge, England) · 2025Review
- Auxin response factor 10 insensitive to miR160regulation induces apospory-like phenotypes iniScience · 2024Article
- Revisiting the female germline cell development.Frontiers in plant science · 2024Review
- OsmiRNA5488 Regulates the Development of Embryo Sacs and TargetsInternational journal of molecular sciences · 2023Article
- 3D cellular morphometrics of ovule primordium development inFrontiers in plant science · 2023Article
- Transcriptional Tuning: How Auxin Strikes Unique Chords in Gene Regulation.Physiologia plantarumReview
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Germline determination is essential for species survival and evolution in multicellular organisms. In most flowering plants, formation of the female germline is initiated with specification of one megaspore mother cell (MMC) in each ovule; however, the molecular mechanism underlying this key event remains unclear. Here we report that spatially restricted auxin signaling promotes MMC fate in Arabidopsis. Our results show that the microRNA160 (miR160) targeted gene ARF17 (AUXIN RESPONSE FACTOR17) is required for promoting MMC specification by genetically interacting with the SPL/NZZ (SPOROCYTELESS/NOZZLE) gene. Alterations of auxin signaling cause formation of supernumerary MMCs in an ARF17- and SPL/NZZ-dependent manner. Furthermore, miR160 and ARF17 are indispensable for attaining a normal auxin maximum at the ovule apex via modulating the expression domain of PIN1 (PIN-FORMED1) auxin transporter. Our findings elucidate the mechanism by which auxin signaling promotes the acquisition of female germline cell fate in plants.
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