Evidence map›Paper›PMID 36379950›Full record

ArticleNature communications2022

Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in mice.

Anneliese S Ashhurst, Matt D Johansen, Joshua W C Maxwell, Skye Stockdale, Caroline L Ashley, Anupriya Aggarwal, Rezwan Siddiquee, Stefan Miemczyk, Duc H Nguyen, Joel P Mackay and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
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  3. Review
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  6. Article
  7. Review
  8. Review
  9. Unraveled role of TLR7-mediated interferon signaling activation in COVID-19.Frontiers in cellular and infection microbiology · 2025
    Review
  10. Upper respiratory tract immunization with PamFrontiers in immunology · 2025
    Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Anneliese S AshhurstSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2006, Australia.
Matt D JohansenCentre for Inflammation, Centenary Institute and Faculty of Science, School of Life Sciences, University of Technology, Sydney, NSW, 2007, Australia.
Joshua W C MaxwellSchool of Chemistry, The University of Sydney, Sydney, NSW, 2006, Australia.
Skye StockdaleSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2006, Australia.
Caroline L AshleySchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2006, Australia.
Anupriya AggarwalKirby Institute, Sydney, NSW, 2052, Australia.
Rezwan SiddiqueeSchool of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, 2006, Australia.
Stefan MiemczykCentre for Inflammation, Centenary Institute and Faculty of Science, School of Life Sciences, University of Technology, Sydney, NSW, 2007, Australia.
Duc H NguyenCentre for Inflammation, Centenary Institute and Faculty of Science, School of Life Sciences, University of Technology, Sydney, NSW, 2007, Australia.
Joel P MackaySchool of Life and Environmental Sciences, The University of Sydney, Sydney, NSW, 2006, Australia.ORCID 0000-0001-7508-8033
Claudio CounoupasSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2006, Australia.
Scott N ByrneSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2006, Australia.ORCID 0000-0003-3029-1710
Stuart TurvilleKirby Institute, Sydney, NSW, 2052, Australia.ORCID 0000-0003-1918-5343
Megan SteainSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2006, Australia.
James A TriccasSchool of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, 2006, Australia.ORCID 0000-0003-3730-2339
Philip M HansbroCentre for Inflammation, Centenary Institute and Faculty of Science, School of Life Sciences, University of Technology, Sydney, NSW, 2007, Australia.ORCID 0000-0002-4741-3035
Richard J PayneSchool of Chemistry, The University of Sydney, Sydney, NSW, 2006, Australia. richard.payne@sydney.edu.ORCID 0000-0002-3618-9226
Warwick J BrittonTuberculosis Research Program Centenary Institute, The University of Sydney, Camperdown, NSW, 2006, Australia. w.britton@centenary.org.au.ORCID 0000-0001-6721-9646
The University of Sydney · AUUniversity of Technology Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Current vaccines against SARS-CoV-2 substantially reduce mortality, but protection against infection is less effective. Enhancing immunity in the respiratory tract, via mucosal vaccination, may provide protection against infection and minimise viral spread. Here, we report testing of a subunit vaccine in mice, consisting of SARS-CoV-2 Spike protein with a TLR2-stimulating adjuvant (Pam

Indexed as

COVID-19Viral VaccinesAnimalsAntibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesHumansImmunity, MucosalLungMiceSARS-CoV-2Spike Glycoprotein, CoronavirusToll-Like Receptor 2VaccinationAntibodies, NeutralizingAntibodies, ViralCOVID-19 VaccinesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2TLR2 protein, humanTlr2 protein, mouseToll-Like Receptor 2Viral Vaccines

Identifiers

PMID36379950
PMCPMC9665025
OpenAlexW4309412440

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.